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. 2020 Oct 30;22(Suppl 1):iv1–iv96. doi: 10.1093/neuonc/noaa200

Table 18.

Estimated Number of Casesa,b of Brain and Other Central Nervous System Tumors Overall and by Behavior, by Major Histology Groupingc, and Histology, 2020, 2021

Histology 2020 Estimated Cases 2021 Estimated Cases
All Malignant Non-Malignant All Malignant Non-Malignant
Tumors of Neuroepithelial Tissue 23,110 21,370 1,740 23,300 21,530 1,770
Pilocytic Astrocytoma 960 960 -- 950 950 --
Diffuse Astrocytoma 1,420 1,420 -- 1,410 1,410 --
Anaplastic Astrocytoma 1,350 1,350 -- 1,340 1,340 --
Unique Astrocytoma Variants 130 100 -- 120 90 --
Glioblastoma 12,800 12,800 -- 12,970 12,970 --
Oligodendroglioma 730 730 -- 730 730 --
Anaplastic Oligodendroglioma 420 420 -- 430 430 --
Oligoastrocytic Tumors -- -- -- -- -- --
Ependymal Tumors 1,310 760 540 1,290 760 540
Glioma Malignant, NOS 1,920 1,920 -- 1,990 1,990 --
Choroid Plexus Tumors 150 -- 140 150 -- 130
Other Neuroepithelial Tumors -- -- -- -- -- --
Neuronal and Mixed Neuronal Glial Tumors 1,110 140 960 1,130 130 1,000
Tumors of the Pineal Region 130 80 -- 120 80 --
Embryonal Tumors 650 640 -- 640 630 --
Tumors of Cranial and Spinal Nerves 5,910 -- 5,870 5,670 -- 5,630
Nerve Sheath Tumors 5,910 -- 5,870 5,670 -- 5,630
Tumors of Meninges 35,260 400 34,850 35,800 390 35,410
Meningioma 34,300 240 34,060 34,840 220 34,620
Mesenchymal Tumors 330 120 210 340 130 220
Primary Melanocytic Lesions -- -- -- -- -- --
Other Neoplasms Related to the Meninges 600 -- -- 600 -- --
Lymphomas and Hematopoietic Neoplasms 1,810 1,810 -- 1,850 1,850 --
Lymphoma 1,770 1,770 -- 1,820 1,820 --
Other Hematopoietic Neoplasms -- -- -- -- -- --
Germ Cell Tumors and Cysts 350 260 90 360 270 90
Germ Cell Tumors, Cysts and Heterotopias 350 260 90 360 270 90
Tumors of Sellar Region 14,430 -- 14,420 14,370 -- 14,360
Tumors of the Pituitary 13,830 -- 13,820 13,770 -- 13,760
Craniopharyngioma 600 -- 600 600 -- 600
Unclassified Tumors 2,950 1,080 1,870 2,810 1,040 1,770
Hemangioma 700 -- 690 640 -- 630
Neoplasm Unspecified 2,100 1,040 1,050 1,970 990 980
All Other 150 -- 120 200 -- 170
TOTAL 83,830 24,970 58,860 84,170 25,130 59,040

a. Source: Estimation based on CBTRUS NPCR and SEER 2000-2017 data for malignant tumors, and NPCR and SEER 2006-2017 data for non-malignant tumors.

b. Rounded to the nearest 10. Numbers may not add up due to rounding.

c. Total estimate is based on overall estimate. Histology-specific estimates may not add up to total.

- Estimated number is less than 50. These cases are included in overall rates.

Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program