Table 22.
Hazards Ratios† And 95% Confidence Intervals for Age Group, Sex, Race, and Ethnicity for Primary Malignant Brain and Other CNS Tumor Histologies, CBTRUS Statistical Report: NPCR, 2001-2016
| Histology | N | Deaths | Age Groups | Sex | Race | Ethnicity (Compared to non-Hispanic) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AYAb (15-39) Years | Adults (40+) Years | Female | Black | AIAN | API | Hispanic | ||||||||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| Pilocytic Astrocytoma | 9,864 | 691 | 1.99 (1.64-2.41) | <0.0001 | 8.38 (6.97-10.06) | <0.0001 | 0.90 (0.78-1.05) | 0.1728 | 1.36 (1.10-1.69) | 0.0051 | 1.64 (0.82-3.30) | 0.1639 | 0.47 (0.24-0.91) | 0.0251 | 0.93 (0.73-1.18) | 0.5476 |
| Diffuse Astrocytoma | 15,177 | 7,984 | 1.51 (1.33-1.72) | <0.0001 | 5.33 (4.73-6.00) | <0.0001 | 0.98 (0.94-1.02) | 0.3615 | 1.08 (0.99-1.17) | 0.0772 | 0.95 (0.74-1.22) | 0.6898 | 0.86 (0.74-1.00) | 0.0537 | 0.82 (0.74-0.89) | <0.0001 |
| Anaplastic Astrocytoma | 11,414 | 7,929 | 0.34 (0.31-0.39) | <0.0001 | 1.07 (0.97-1.19) | 0.1800 | 0.99 (0.95-1.04) | 0.6701 | 1.04 (0.95-1.13) | 0.3694 | 1.01 (0.77-1.32) | 0.9357 | 0.80 (0.69-0.93) | 0.0041 | 0.78 (0.72-0.86) | <0.0001 |
| Unique Astrocytoma Variants | 1,269 | 511 | 1.30 (0.93-1.82) | 0.1211 | 5.25 (3.88-7.10) | <0.0001 | 0.94 (0.79-1.13) | 0.5260 | 0.72 (0.52-0.99) | 0.0401 | 1.75 (0.86-3.54) | 0.1203 | 0.88 (0.51-1.53) | 0.6536 | 0.60 (0.43-0.85) | 0.0034 |
| Glioblastoma | 92,191 | 84,294 | 0.72 (0.66-0.78) | <0.0001 | 1.57 (1.46-1.70) | <0.0001 | 1.00 (0.99-1.02) | 0.6790 | 0.97 (0.94-1.00) | 0.0407 | 1.02 (0.92-1.13) | 0.7723 | 0.83 (0.79-0.88) | <0.0001 | 0.89 (0.86-0.92) | <0.0001 |
| Oligodendroglioma | 7,632 | 1,989 | 2.57 (1.54-4.30) | 0.0003 | 5.62 (3.38-9.36) | <0.0001 | 0.86 (0.79-0.94) | 0.0012 | 1.38 (1.16-1.64) | 0.0003 | 0.97 (0.54-1.76) | 0.9327 | 0.75 (0.55-1.01) | 0.0556 | 0.64 (0.54-0.78) | <0.0001 |
| Anaplastic Oligodendroglioma | 3,320 | 1,474 | 0.36 (0.20-0.62) | 0.0003 | 0.69 (0.40-1.20) | 0.1938 | 0.99 (0.89-1.10) | 0.8601 | 1.33 (1.08-1.64) | 0.0065 | 0.46 (0.17-1.24) | 0.1245 | 0.74 (0.55-0.99) | 0.0423 | 0.79 (0.66-0.95) | 0.0135 |
| Oligoastrocytic Tumors | 5,276 | 2,295 | 1.59 (1.08-2.34) | 0.0181 | 3.48 (2.38-5.10) | <0.0001 | 0.94 (0.87-1.02) | 0.1592 | 1.21 (1.02-1.42) | 0.0243 | 1.25 (0.81-1.92) | 0.3183 | 0.79 (0.61-1.04) | 0.0939 | 0.78 (0.67-0.91) | 0.0016 |
| Ependymal Tumors | 7,675 | 1,505 | 0.49 (0.42-0.57) | <0.0001 | 0.89 (0.79-1.01) | 0.0610 | 0.75 (0.67-0.83) | <0.0001 | 1.29 (1.10-1.50) | 0.0017 | 1.14 (0.72-1.82) | 0.5766 | 0.79 (0.59-1.07) | 0.1341 | 0.88 (0.75-1.02) | 0.0956 |
| Glioma Malignant, NOS | 12,440 | 5,388 | 0.72 (0.65-0.79) | <0.0001 | 2.81 (2.64-3.00) | <0.0001 | 0.95 (0.90-1.00) | 0.0408 | 1.11 (1.02-1.20) | 0.0156 | 1.05 (0.77-1.42) | 0.7671 | 1.01 (0.86-1.19) | 0.8665 | 1.03 (0.95-1.13) | 0.4658 |
| Choroid Plexus Tumors | 240 | 92 | 0.54 (0.26-1.11) | 0.0962 | 1.20 (0.71-2.05) | 0.4942 | 0.90 (0.59-1.37) | 0.6170 | 1.04 (0.56-1.94) | 0.9013 | 2.40 (0.71-8.09) | 0.1597 | 4.93 (2.19-11.10) | 0.0001 | 0.43 (0.23-0.83) | 0.0124 |
| Other Neuroepithelial Tumors | 121 | 40 | 1.56 (0.42-5.82) | 0.5048 | 7.49 (2.33-24.09) | 0.0007 | 0.48 (0.24-0.94) | 0.0317 | 0.76 (0.22-2.61) | 0.6608 | ** | ** | ** | ** | 0.69 (0.23-2.03) | 0.4994 |
| Neuronal and Mixed Neuronal Glial Tumors | 1,563 | 475 | 1.24 (0.82-1.89) | 0.3086 | 1.49 (1.01-2.20) | 0.0423 | 0.85 (0.70-1.02) | 0.0782 | 1.30 (0.98-1.72) | 0.0670 | 3.30 (1.62-6.71) | 0.0010 | 0.90 (0.58-1.38) | 0.6145 | 0.94 (0.70-1.27) | 0.6923 |
| Tumors of the Pineal Region | 740 | 246 | 0.58 (0.42-0.80) | 0.0008 | 1.00 (0.73-1.36) | 0.9817 | 0.69 (0.54-0.89) | 0.0049 | 0.99 (0.73-1.34) | 0.9373 | 1.08 (0.39-2.94) | 0.8864 | 0.38 (0.14-1.03) | 0.0580 | 1.08 (0.75-1.56) | 0.6697 |
| Embryonal Tumors | 6,834 | 2,605 | 0.80 (0.73-0.88) | <0.0001 | 1.66 (1.48-1.86) | <0.0001 | 1.01 (0.94-1.09) | 0.7680 | 1.27 (1.13-1.43) | <0.0001 | 1.13 (0.76-1.68) | 0.5392 | 0.95 (0.77-1.18) | 0.6344 | 0.84 (0.76-0.93) | 0.0012 |
| Nerve Sheath Tumors | 339 | 127 | 0.71 (0.32-1.56) | 0.3922 | 0.86 (0.41-1.77) | 0.6784 | 0.71 (0.50-1.02) | 0.0631 | 1.31 (0.80-2.15) | 0.2891 | ** | ** | 0.09 (0.01-0.65) | 0.0167 | 1.23 (0.66-2.26) | 0.5162 |
| Meningioma | 2,736 | 1,188 | 0.84 (0.43-1.66) | 0.6184 | 2.11 (1.13-3.93) | 0.0192 | 0.73 (0.65-0.81) | <0.0001 | 0.96 (0.83-1.12) | 0.6068 | 0.57 (0.21-1.52) | 0.2619 | 0.74 (0.55-1.01) | 0.0544 | 0.70 (0.56-0.89) | 0.0034 |
| Mesenchymal Tumors | 704 | 278 | 0.70 (0.45-1.09) | 0.1161 | 0.98 (0.67-1.43) | 0.9064 | 0.98 (0.77-1.24) | 0.8657 | 1.10 (0.75-1.62) | 0.6282 | 1.31 (0.48-3.55) | 0.5956 | 0.56 (0.31-1.00) | 0.0496 | 0.93 (0.63-1.36) | 0.7010 |
| Primary Melanocytic Lesions | 100 | 76 | 0.42 (0.17-1.02) | 0.0548 | 0.63 (0.30-1.31) | 0.2140 | 0.83 (0.50-1.37) | 0.4595 | 1.91 (0.66-5.49) | 0.2321 | ** | ** | 1.19 (0.42-3.39) | 0.7463 | 2.13 (0.89-5.11) | 0.0897 |
| Other Neoplasms Related to the Meninges | 443 | 144 | 1.34 (0.46-3.93) | 0.5880 | 3.09 (1.11-8.61) | 0.0305 | 0.83 (0.59-1.16) | 0.2743 | 0.99 (0.56-1.78) | 0.9854 | 3.12 (0.98-9.90) | 0.0535 | 0.63 (0.25-1.58) | 0.3281 | 1.01 (0.59-1.73) | 0.9620 |
| Lymphoma | 12,068 | 7,997 | 2.06 (1.21-3.50) | 0.0079 | 3.74 (2.21-6.32) | <0.0001 | 0.93 (0.89-0.97) | 0.0018 | 1.21 (1.12-1.31) | <0.0001 | 1.32 (1.03-1.70) | 0.0276 | 0.86 (0.77-0.95) | 0.0049 | 0.87 (0.80-0.94) | 0.0006 |
| Other Hemopoietic Neoplasms | 316 | 112 | 3.14 (0.87-11.28) | 0.0799 | 9.46 (2.98-30.04) | 0.0001 | 0.85 (0.58-1.24) | 0.3943 | 0.82 (0.48-1.39) | 0.4568 | 0.98 (0.24-4.04) | 0.9774 | 0.35 (0.09-1.45) | 0.1490 | 1.09 (0.64-1.86) | 0.7455 |
| Germ Cell Tumors, Cysts and Heterotopias | 2,027 | 269 | 0.98 (0.75-1.27) | 0.8531 | 3.66 (2.35-5.70) | <0.0001 | 1.43 (1.09-1.89) | 0.0110 | 0.85 (0.55-1.31) | 0.4671 | 1.94 (0.62-6.11) | 0.2561 | 0.60 (0.38-0.96) | 0.0331 | 0.84 (0.61-1.16) | 0.2863 |
| Tumors of the Pituitary | 261 | 77 | ** | ** | ** | ** | 0.58 (0.36-0.93) | 0.0252 | 1.58 (0.94-2.65) | 0.0866 | 1.16 (0.16-8.71) | 0.8827 | 0.37 (0.05-2.73) | 0.3320 | 0.76 (0.30-1.91) | 0.5587 |
| Neoplasm Unspecified | 5,013 | 4,081 | 0.71 (0.56-0.90) | 0.0040 | 2.32 (1.93-2.78) | <0.0001 | 0.98 (0.92-1.04) | 0.4526 | 0.73 (0.66-0.81) | <0.0001 | 0.95 (0.67-1.34) | 0.7667 | 0.90 (0.73-1.11) | 0.3268 | 0.89 (0.78-1.00) | 0.0541 |
a.Children as defined by the National Cancer Institute, see: http://www.cancer.gov/researchandfunding/snapshots/pediatric.
b.Adolescents and Young Adults (AYA), as defined by the National Cancer Institute, see: http://www.cancer.gov/cancertopics/aya.
†Reference Categories are Children (<14 years) for Age group, Male for Sex, White for Race, and Non-Hispanic for Ethnicity.
** Cannot be calculated
Abbreviations: AYA, Adolescents and Young Adults; CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; CI, confidence interval; NOS, not otherwise specified