Table 3.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Brain and Other Central Nervous System Tumors by Major Histology Grouping, Histology, Behavior, and Sex, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2013-2017
| Histology | Total | Male | Female | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 year total | Annual average | % of all tumors | Median Age | Rate | 95% CI | 5 year total | Annual average | % Malignant | % Non-Malignant | Rate | 95% CI | 5 year total | Annual average | % Malignant | % Non-Malignant | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 113,056 | 22,611 | 27.2% | 57 | 6.56 | 6.52-6.60 | 63,606 | 12,721 | 92.8% | 7.2% | 7.71 | 7.65-7.77 | 49,450 | 9,890 | 92.3% | 7.7% | 5.55 | 5.50-5.60 |
| Pilocytic Astrocytoma | 5,167 | 1,033 | 1.2% | 12 | 0.35 | 0.34-0.36 | 2,681 | 536 | 100.0% | 0.0% | 0.36 | 0.35-0.37 | 2,486 | 497 | 100.0% | 0.0% | 0.34 | 0.33-0.36 |
| Diffuse Astrocytoma | 7,428 | 1,486 | 1.8% | 46 | 0.45 | 0.44-0.46 | 4,162 | 832 | 100.0% | 0.0% | 0.52 | 0.50-0.54 | 3,266 | 653 | 100.0% | 0.0% | 0.39 | 0.38-0.40 |
| Anaplastic Astrocytoma | 7,116 | 1,423 | 1.7% | 53 | 0.42 | 0.41-0.43 | 3,892 | 778 | 100.0% | 0.0% | 0.48 | 0.46-0.49 | 3,224 | 645 | 100.0% | 0.0% | 0.37 | 0.36-0.38 |
| Unique Astrocytoma Variants | 1,123 | 225 | 0.3% | 23 | 0.07 | 0.07-0.08 | 611 | 122 | 68.9% | 31.1% | 0.08 | 0.07-0.09 | 512 | 102 | 68.0% | 32.0% | 0.07 | 0.06-0.07 |
| Malignant | 769 | 154 | -- | 32 | 0.05 | 0.04-0.05 | 421 | 84 | -- | -- | 0.05 | 0.05-0.06 | 348 | 70 | -- | -- | 0.04 | 0.04-0.05 |
| Non-Malignant | 354 | 71 | -- | 11 | 0.02 | 0.02-0.03 | 190 | 38 | -- | -- | 0.03 | 0.02-0.03 | 164 | 33 | -- | -- | 0.02 | 0.02-0.03 |
| Glioblastoma | 60,056 | 12,011 | 14.5% | 65 | 3.23 | 3.20-3.25 | 34,793 | 6,959 | 100.0% | 0.0% | 4.03 | 3.98-4.07 | 25,263 | 5,053 | 100.0% | 0.0% | 2.54 | 2.50-2.57 |
| Oligodendroglioma | 3,698 | 740 | 0.9% | 44 | 0.23 | 0.23-0.24 | 2,031 | 406 | 100.0% | 0.0% | 0.26 | 0.25-0.27 | 1,667 | 333 | 100.0% | 0.0% | 0.21 | 0.20-0.22 |
| Anaplastic Oligodendroglioma | 1,859 | 372 | 0.4% | 49 | 0.11 | 0.11-0.12 | 1,036 | 207 | 99.9% | 0.1% | 0.13 | 0.12-0.14 | 823 | 165 | 100.0% | 0.0% | 0.10 | 0.09-0.11 |
| Oligoastrocytic Tumors | 1,572 | 314 | 0.4% | 42 | 0.10 | 0.09-0.10 | 893 | 179 | 100.0% | 0.0% | 0.11 | 0.11-0.12 | 679 | 136 | 99.9% | 0.1% | 0.08 | 0.08-0.09 |
| Ependymal Tumors | 6,843 | 1,369 | 1.6% | 45 | 0.42 | 0.41-0.43 | 3,911 | 782 | 55.6% | 44.4% | 0.49 | 0.47-0.50 | 2,932 | 586 | 61.4% | 38.6% | 0.36 | 0.35-0.37 |
| Malignant | 3,972 | 794 | -- | 23 | 0.25 | 0.24-0.26 | 2,173 | 435 | -- | -- | 0.27 | 0.26-0.29 | 1,799 | 360 | -- | -- | 0.22 | 0.21-0.24 |
| Non-Malignant | 2,871 | 574 | -- | 48 | 0.17 | 0.17-0.18 | 1,738 | 348 | -- | -- | 0.21 | 0.20-0.22 | 1,133 | 227 | -- | -- | 0.14 | 0.13-0.14 |
| Glioma Malignant, NOS | 8,093 | 1,619 | 1.9% | 36 | 0.51 | 0.50-0.52 | 4,089 | 818 | 100.0% | 0.0% | 0.53 | 0.51-0.55 | 4,004 | 801 | 100.0% | 0.0% | 0.49 | 0.47-0.50 |
| Choroid Plexus Tumors | 827 | 165 | 0.2% | 20 | 0.05 | 0.05-0.06 | 425 | 85 | 16.7% | 83.3% | 0.06 | 0.05-0.06 | 402 | 80 | 14.2% | 85.8% | 0.05 | 0.05-0.06 |
| Malignant | 128 | 26 | -- | 2 | 0.01 | 0.01-0.01 | 71 | 14 | -- | -- | 0.01 | 0.01-0.01 | 57 | 11 | -- | -- | 0.01 | 0.01-0.01 |
| Non-Malignant | 699 | 140 | -- | 24 | 0.05 | 0.04-0.05 | 354 | 71 | -- | -- | 0.05 | 0.04-0.05 | 345 | 69 | -- | -- | 0.04 | 0.04-0.05 |
| Other Neuroepithelial Tumors | 107 | 21 | 0.0% | 34 | 0.01 | 0.01-0.01 | 40 | 8 | 50.0% | 50.0% | 0.01 | 0.00-0.01 | 67 | 13 | 68.7% | 31.3% | 0.01 | 0.01-0.01 |
| Malignant | 66 | 13 | -- | 26.5 | 0.00 | 0.00-0.01 | 20 | 4 | -- | -- | 0.00 | 0.00-0.00 | 46 | 9 | -- | -- | 0.01 | 0.00-0.01 |
| Non-Malignant | 41 | 8 | -- | 43 | 0.00 | 0.00-0.00 | 20 | 4 | -- | -- | 0.00 | 0.00-0.00 | 21 | 4 | -- | -- | 0.00 | 0.00-0.00 |
| Neuronal and Mixed Neuronal Glial Tumors | 4,934 | 987 | 1.2% | 26 | 0.32 | 0.31-0.33 | 2,672 | 534 | 20.5% | 79.5% | 0.34 | 0.33-0.36 | 2,262 | 452 | 17.6% | 82.4% | 0.29 | 0.28-0.31 |
| Malignant | 947 | 189 | -- | 52 | 0.06 | 0.05-0.06 | 549 | 110 | -- | -- | 0.07 | 0.06-0.07 | 398 | 80 | -- | -- | 0.05 | 0.04-0.05 |
| Non-Malignant | 3,987 | 797 | -- | 22 | 0.26 | 0.25-0.27 | 2,123 | 425 | -- | -- | 0.28 | 0.27-0.29 | 1,864 | 373 | -- | -- | 0.25 | 0.24-0.26 |
| Tumors of the Pineal Region | 787 | 157 | 0.2% | 34 | 0.05 | 0.05-0.05 | 329 | 66 | 69.6% | 30.4% | 0.04 | 0.04-0.05 | 458 | 92 | 47.6% | 52.4% | 0.06 | 0.05-0.06 |
| Malignant | 447 | 89 | -- | 27 | 0.03 | 0.03-0.03 | 229 | 46 | -- | -- | 0.03 | 0.03-0.03 | 218 | 44 | -- | -- | 0.03 | 0.02-0.03 |
| Non-Malignant | 340 | 68 | -- | 43 | 0.02 | 0.02-0.02 | 100 | 20 | -- | -- | 0.01 | 0.01-0.02 | 240 | 48 | -- | -- | 0.03 | 0.03-0.03 |
| Embryonal Tumors | 3,446 | 689 | 0.8% | 9 | 0.23 | 0.23-0.24 | 2,041 | 408 | 98.0% | 2.0% | 0.27 | 0.26-0.29 | 1,405 | 281 | 95.9% | 4.1% | 0.19 | 0.18-0.20 |
| Tumors of Cranial and Spinal Nerves | 35,600 | 7,120 | 8.6% | 57 | 2.03 | 2.01-2.05 | 17,038 | 3,408 | 0.7% | 99.3% | 2.02 | 1.99-2.06 | 18,562 | 3,712 | 0.6% | 99.4% | 2.05 | 2.02-2.08 |
| Nerve Sheath Tumors | 35,560 | 7,112 | 8.6% | 57 | 2.03 | 2.01-2.05 | 17,013 | 3,403 | 0.7% | 99.3% | 2.02 | 1.99-2.05 | 18,547 | 3,709 | 0.6% | 99.4% | 2.04 | 2.01-2.07 |
| Malignant | 223 | 45 | -- | 54 | 0.01 | 0.01-0.02 | 112 | 22 | -- | -- | 0.01 | 0.01-0.02 | 111 | 22 | -- | -- | 0.01 | 0.01-0.02 |
| Non-Malignant | 35,337 | 7,067 | -- | 57 | 2.02 | 1.99-2.04 | 16,901 | 3,380 | -- | -- | 2.01 | 1.98-2.04 | 18,436 | 3,687 | -- | -- | 2.03 | 2.00-2.06 |
| Other Tumors of Cranial and Spinal Nerves | 40 | 8 | 0.0% | 54.5 | 0.00 | 0.00-0.00 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| Tumors of Meninges | 163,619 | 32,724 | 39.4% | 66 | 9.09 | 9.04-9.13 | 45,497 | 9,099 | 2.6% | 97.4% | 5.56 | 5.51-5.61 | 118,122 | 23,624 | 1.1% | 98.9% | 12.22 | 12.15-12.29 |
| Meningioma | 159,038 | 31,808 | 38.3% | 66 | 8.81 | 8.77-8.86 | 43,082 | 8,616 | 1.8% | 98.2% | 5.26 | 5.21-5.31 | 115,956 | 23,191 | 0.8% | 99.2% | 11.96 | 11.89-12.03 |
| Malignant | 1,750 | 350 | -- | 65 | 0.10 | 0.09-0.10 | 768 | 154 | -- | -- | 0.09 | 0.08-0.10 | 982 | 196 | -- | -- | 0.10 | 0.09-0.11 |
| Non-Malignant | 157,288 | 31,458 | -- | 66 | 8.72 | 8.67-8.76 | 42,314 | 8,463 | -- | -- | 5.17 | 5.12-5.22 | 114,974 | 22,995 | -- | -- | 11.86 | 11.79-11.93 |
| Mesenchymal Tumors | 1,462 | 292 | 0.4% | 49 | 0.09 | 0.08-0.09 | 722 | 144 | 34.9% | 65.1% | 0.09 | 0.08-0.10 | 740 | 148 | 30.8% | 69.2% | 0.09 | 0.08-0.09 |
| Primary Melanocytic Lesions | 108 | 22 | 0.0% | 57.5 | 0.01 | 0.00-0.01 | 55 | 11 | 81.8% | 18.2% | 0.01 | 0.00-0.01 | 53 | 11 | 50.9% | 49.1% | 0.01 | 0.00-0.01 |
| Other Neoplasms Related to the Meninges | 3,011 | 602 | 0.7% | 49 | 0.18 | 0.17-0.19 | 1,638 | 328 | 8.2% | 91.8% | 0.20 | 0.19-0.21 | 1,373 | 275 | 8.4% | 91.6% | 0.16 | 0.15-0.17 |
| Lymphomas and Hematopoietic Neoplasms | 8,150 | 1,630 | 2.0% | 67 | 0.45 | 0.44-0.46 | 4,129 | 826 | -- | -- | 0.49 | 0.48-0.51 | 4,021 | 804 | -- | -- | 0.41 | 0.40-0.42 |
| Lymphoma | 7,919 | 1,584 | 1.9% | 67 | 0.43 | 0.42-0.44 | 4,002 | 800 | 100.0% | 0.0% | 0.48 | 0.46-0.49 | 3,917 | 783 | 100.0% | 0.0% | 0.40 | 0.38-0.41 |
| Other Hematopoietic Neoplasms | 231 | 46 | 0.1% | 47 | 0.01 | 0.01-0.02 | 127 | 25 | 96.1% | 3.9% | 0.02 | 0.01-0.02 | 104 | 21 | 92.3% | 7.7% | 0.01 | 0.01-0.02 |
| Germ Cell Tumors and Cysts | 1,585 | 317 | 0.4% | 16 | 0.11 | 0.10-0.11 | 1,094 | 219 | 76.7% | 23.3% | 0.14 | 0.14-0.15 | 491 | 98 | 52.1% | 47.9% | 0.07 | 0.06-0.07 |
| Germ Cell Tumors, Cysts and Heterotopias | 1,585 | 317 | 0.4% | 16 | 0.11 | 0.10-0.11 | 1,094 | 219 | 76.7% | 23.3% | 0.14 | 0.14-0.15 | 491 | 98 | 52.1% | 47.9% | 0.07 | 0.06-0.07 |
| Malignant | 1,095 | 219 | -- | 15 | 0.07 | 0.07-0.08 | 839 | 168 | -- | -- | 0.11 | 0.10-0.12 | 256 | 51 | -- | -- | 0.04 | 0.03-0.04 |
| Non-Malignant | 490 | 98 | -- | 25.5 | 0.03 | 0.03-0.03 | 255 | 51 | -- | -- | 0.03 | 0.03-0.04 | 235 | 47 | -- | -- | 0.03 | 0.03-0.03 |
| Tumors of Sellar Region | 73,340 | 14,668 | 17.7% | 51 | 4.39 | 4.36-4.43 | 33,190 | 6,638 | 0.3% | 99.7% | 4.02 | 3.98-4.07 | 40,150 | 8,030 | 0.1% | 99.9% | 4.85 | 4.80-4.90 |
| Tumors of the Pituitary | 70,211 | 14,042 | 16.9% | 51 | 4.20 | 4.17-4.23 | 31,611 | 6,322 | 0.3% | 99.7% | 3.82 | 3.78-3.87 | 38,600 | 7,720 | 0.1% | 99.9% | 4.66 | 4.61-4.71 |
| Malignant | 142 | 28 | -- | 57 | 0.01 | 0.01-0.01 | 86 | 17 | -- | -- | 0.01 | 0.01-0.01 | 56 | 11 | -- | -- | 0.01 | 0.00-0.01 |
| Non-Malignant | 70,069 | 14,014 | -- | 51 | 4.19 | 4.16-4.22 | 31,525 | 6,305 | -- | -- | 3.81 | 3.77-3.86 | 38,544 | 7,709 | -- | -- | 4.65 | 4.61-4.70 |
| Craniopharyngioma | 3,129 | 626 | 0.8% | 44 | 0.19 | 0.19-0.20 | 1,579 | 316 | 0.6% | 99.4% | 0.20 | 0.19-0.21 | 1,550 | 310 | 0.3% | 99.7% | 0.19 | 0.18-0.20 |
| Unclassified Tumors | 20,061 | 4,012 | 4.8% | 64 | 1.16 | 1.14-1.17 | 9,087 | 1,817 | 34.9% | 65.1% | 1.15 | 1.12-1.17 | 10,974 | 2,195 | 31.8% | 68.2% | 1.18 | 1.15-1.20 |
| Hemangioma | 5,731 | 1,146 | 1.4% | 50 | 0.34 | 0.34-0.35 | 2,518 | 504 | 0.4% | 99.6% | 0.31 | 0.30-0.33 | 3,213 | 643 | 0.4% | 99.6% | 0.38 | 0.36-0.39 |
| Neoplasm Unspecified | 14,136 | 2,827 | 3.4% | 70 | 0.80 | 0.79-0.82 | 6,451 | 1,290 | 48.6% | 51.4% | 0.82 | 0.80-0.84 | 7,685 | 1,537 | 44.9% | 55.1% | 0.79 | 0.77-0.81 |
| Malignant | 6,587 | 1,317 | -- | 76 | 0.36 | 0.35-0.37 | 3,135 | 627 | -- | -- | 0.40 | 0.39-0.41 | 3,452 | 690 | -- | -- | 0.33 | 0.32-0.35 |
| Non-Malignant | 7,549 | 1,510 | -- | 63 | 0.44 | 0.43-0.45 | 3,316 | 663 | -- | -- | 0.42 | 0.41-0.44 | 4,233 | 847 | -- | -- | 0.46 | 0.44-0.47 |
| All Other | 194 | 39 | 0.0% | 66 | 0.01 | 0.01-0.01 | 118 | 24 | 20.3% | 79.7% | 0.02 | 0.01-0.02 | 76 | 15 | 31.6% | 68.4% | 0.01 | 0.01-0.01 |
| TOTAL c | 415,411 | 83,082 | -- | 60 | 23.79 | 23.71-23.86 | 173,641 | 34,728 | 39.5% | 60.5% | 21.09 | 20.99-21.20 | 241,770 | 48,354 | 22.7% | 77.3% | 26.31 | 26.21-26.42 |
| Malignant | 123,484 | 24,697 | 29.7% | 60 | 7.08 | 7.04-7.12 | 68,578 | 13,716 | -- | -- | 8.30 | 8.24-8.36 | 54,906 | 10,981 | -- | -- | 6.01 | 5.95-6.06 |
| Non-Malignant | 291,927 | 58,385 | 70.3% | 61 | 16.71 | 16.64-16.77 | 105,063 | 21,013 | -- | -- | 12.80 | 12.72-12.88 | 186,864 | 37,373 | -- | -- | 20.31 | 20.21-20.40 |
a. Annual average cases are calculated by dividing the five-year total by five.
b. Rates are per 100,000 and are age-adjusted to the 2000 US standard population.
c. Refers to all brain tumors including histologies not presented in this table.
-- Counts and rates are not presented when fewer than 20 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified