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. 2020 Oct 30;22(Suppl 1):iv1–iv96. doi: 10.1093/neuonc/noaa200

Table 3.

Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Brain and Other Central Nervous System Tumors by Major Histology Grouping, Histology, Behavior, and Sex, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2013-2017

Histology Total Male Female
5 year total Annual average % of all tumors Median Age Rate 95% CI 5 year total Annual average % Malignant % Non-Malignant Rate 95% CI 5 year total Annual average % Malignant % Non-Malignant Rate 95% CI
Tumors of Neuroepithelial Tissue 113,056 22,611 27.2% 57 6.56 6.52-6.60 63,606 12,721 92.8% 7.2% 7.71 7.65-7.77 49,450 9,890 92.3% 7.7% 5.55 5.50-5.60
Pilocytic Astrocytoma 5,167 1,033 1.2% 12 0.35 0.34-0.36 2,681 536 100.0% 0.0% 0.36 0.35-0.37 2,486 497 100.0% 0.0% 0.34 0.33-0.36
Diffuse Astrocytoma 7,428 1,486 1.8% 46 0.45 0.44-0.46 4,162 832 100.0% 0.0% 0.52 0.50-0.54 3,266 653 100.0% 0.0% 0.39 0.38-0.40
Anaplastic Astrocytoma 7,116 1,423 1.7% 53 0.42 0.41-0.43 3,892 778 100.0% 0.0% 0.48 0.46-0.49 3,224 645 100.0% 0.0% 0.37 0.36-0.38
Unique Astrocytoma Variants 1,123 225 0.3% 23 0.07 0.07-0.08 611 122 68.9% 31.1% 0.08 0.07-0.09 512 102 68.0% 32.0% 0.07 0.06-0.07
Malignant 769 154 -- 32 0.05 0.04-0.05 421 84 -- -- 0.05 0.05-0.06 348 70 -- -- 0.04 0.04-0.05
Non-Malignant 354 71 -- 11 0.02 0.02-0.03 190 38 -- -- 0.03 0.02-0.03 164 33 -- -- 0.02 0.02-0.03
Glioblastoma 60,056 12,011 14.5% 65 3.23 3.20-3.25 34,793 6,959 100.0% 0.0% 4.03 3.98-4.07 25,263 5,053 100.0% 0.0% 2.54 2.50-2.57
Oligodendroglioma 3,698 740 0.9% 44 0.23 0.23-0.24 2,031 406 100.0% 0.0% 0.26 0.25-0.27 1,667 333 100.0% 0.0% 0.21 0.20-0.22
Anaplastic Oligodendroglioma 1,859 372 0.4% 49 0.11 0.11-0.12 1,036 207 99.9% 0.1% 0.13 0.12-0.14 823 165 100.0% 0.0% 0.10 0.09-0.11
Oligoastrocytic Tumors 1,572 314 0.4% 42 0.10 0.09-0.10 893 179 100.0% 0.0% 0.11 0.11-0.12 679 136 99.9% 0.1% 0.08 0.08-0.09
Ependymal Tumors 6,843 1,369 1.6% 45 0.42 0.41-0.43 3,911 782 55.6% 44.4% 0.49 0.47-0.50 2,932 586 61.4% 38.6% 0.36 0.35-0.37
Malignant 3,972 794 -- 23 0.25 0.24-0.26 2,173 435 -- -- 0.27 0.26-0.29 1,799 360 -- -- 0.22 0.21-0.24
Non-Malignant 2,871 574 -- 48 0.17 0.17-0.18 1,738 348 -- -- 0.21 0.20-0.22 1,133 227 -- -- 0.14 0.13-0.14
Glioma Malignant, NOS 8,093 1,619 1.9% 36 0.51 0.50-0.52 4,089 818 100.0% 0.0% 0.53 0.51-0.55 4,004 801 100.0% 0.0% 0.49 0.47-0.50
Choroid Plexus Tumors 827 165 0.2% 20 0.05 0.05-0.06 425 85 16.7% 83.3% 0.06 0.05-0.06 402 80 14.2% 85.8% 0.05 0.05-0.06
Malignant 128 26 -- 2 0.01 0.01-0.01 71 14 -- -- 0.01 0.01-0.01 57 11 -- -- 0.01 0.01-0.01
Non-Malignant 699 140 -- 24 0.05 0.04-0.05 354 71 -- -- 0.05 0.04-0.05 345 69 -- -- 0.04 0.04-0.05
Other Neuroepithelial Tumors 107 21 0.0% 34 0.01 0.01-0.01 40 8 50.0% 50.0% 0.01 0.00-0.01 67 13 68.7% 31.3% 0.01 0.01-0.01
Malignant 66 13 -- 26.5 0.00 0.00-0.01 20 4 -- -- 0.00 0.00-0.00 46 9 -- -- 0.01 0.00-0.01
Non-Malignant 41 8 -- 43 0.00 0.00-0.00 20 4 -- -- 0.00 0.00-0.00 21 4 -- -- 0.00 0.00-0.00
Neuronal and Mixed Neuronal Glial Tumors 4,934 987 1.2% 26 0.32 0.31-0.33 2,672 534 20.5% 79.5% 0.34 0.33-0.36 2,262 452 17.6% 82.4% 0.29 0.28-0.31
Malignant 947 189 -- 52 0.06 0.05-0.06 549 110 -- -- 0.07 0.06-0.07 398 80 -- -- 0.05 0.04-0.05
Non-Malignant 3,987 797 -- 22 0.26 0.25-0.27 2,123 425 -- -- 0.28 0.27-0.29 1,864 373 -- -- 0.25 0.24-0.26
Tumors of the Pineal Region 787 157 0.2% 34 0.05 0.05-0.05 329 66 69.6% 30.4% 0.04 0.04-0.05 458 92 47.6% 52.4% 0.06 0.05-0.06
Malignant 447 89 -- 27 0.03 0.03-0.03 229 46 -- -- 0.03 0.03-0.03 218 44 -- -- 0.03 0.02-0.03
Non-Malignant 340 68 -- 43 0.02 0.02-0.02 100 20 -- -- 0.01 0.01-0.02 240 48 -- -- 0.03 0.03-0.03
Embryonal Tumors 3,446 689 0.8% 9 0.23 0.23-0.24 2,041 408 98.0% 2.0% 0.27 0.26-0.29 1,405 281 95.9% 4.1% 0.19 0.18-0.20
Tumors of Cranial and Spinal Nerves 35,600 7,120 8.6% 57 2.03 2.01-2.05 17,038 3,408 0.7% 99.3% 2.02 1.99-2.06 18,562 3,712 0.6% 99.4% 2.05 2.02-2.08
Nerve Sheath Tumors 35,560 7,112 8.6% 57 2.03 2.01-2.05 17,013 3,403 0.7% 99.3% 2.02 1.99-2.05 18,547 3,709 0.6% 99.4% 2.04 2.01-2.07
Malignant 223 45 -- 54 0.01 0.01-0.02 112 22 -- -- 0.01 0.01-0.02 111 22 -- -- 0.01 0.01-0.02
Non-Malignant 35,337 7,067 -- 57 2.02 1.99-2.04 16,901 3,380 -- -- 2.01 1.98-2.04 18,436 3,687 -- -- 2.03 2.00-2.06
Other Tumors of Cranial and Spinal Nerves 40 8 0.0% 54.5 0.00 0.00-0.00 -- -- -- -- -- -- -- -- -- -- --
Tumors of Meninges 163,619 32,724 39.4% 66 9.09 9.04-9.13 45,497 9,099 2.6% 97.4% 5.56 5.51-5.61 118,122 23,624 1.1% 98.9% 12.22 12.15-12.29
Meningioma 159,038 31,808 38.3% 66 8.81 8.77-8.86 43,082 8,616 1.8% 98.2% 5.26 5.21-5.31 115,956 23,191 0.8% 99.2% 11.96 11.89-12.03
Malignant 1,750 350 -- 65 0.10 0.09-0.10 768 154 -- -- 0.09 0.08-0.10 982 196 -- -- 0.10 0.09-0.11
Non-Malignant 157,288 31,458 -- 66 8.72 8.67-8.76 42,314 8,463 -- -- 5.17 5.12-5.22 114,974 22,995 -- -- 11.86 11.79-11.93
Mesenchymal Tumors 1,462 292 0.4% 49 0.09 0.08-0.09 722 144 34.9% 65.1% 0.09 0.08-0.10 740 148 30.8% 69.2% 0.09 0.08-0.09
Primary Melanocytic Lesions 108 22 0.0% 57.5 0.01 0.00-0.01 55 11 81.8% 18.2% 0.01 0.00-0.01 53 11 50.9% 49.1% 0.01 0.00-0.01
Other Neoplasms Related to the Meninges 3,011 602 0.7% 49 0.18 0.17-0.19 1,638 328 8.2% 91.8% 0.20 0.19-0.21 1,373 275 8.4% 91.6% 0.16 0.15-0.17
Lymphomas and Hematopoietic Neoplasms 8,150 1,630 2.0% 67 0.45 0.44-0.46 4,129 826 -- -- 0.49 0.48-0.51 4,021 804 -- -- 0.41 0.40-0.42
Lymphoma 7,919 1,584 1.9% 67 0.43 0.42-0.44 4,002 800 100.0% 0.0% 0.48 0.46-0.49 3,917 783 100.0% 0.0% 0.40 0.38-0.41
Other Hematopoietic Neoplasms 231 46 0.1% 47 0.01 0.01-0.02 127 25 96.1% 3.9% 0.02 0.01-0.02 104 21 92.3% 7.7% 0.01 0.01-0.02
Germ Cell Tumors and Cysts 1,585 317 0.4% 16 0.11 0.10-0.11 1,094 219 76.7% 23.3% 0.14 0.14-0.15 491 98 52.1% 47.9% 0.07 0.06-0.07
Germ Cell Tumors, Cysts and Heterotopias 1,585 317 0.4% 16 0.11 0.10-0.11 1,094 219 76.7% 23.3% 0.14 0.14-0.15 491 98 52.1% 47.9% 0.07 0.06-0.07
Malignant 1,095 219 -- 15 0.07 0.07-0.08 839 168 -- -- 0.11 0.10-0.12 256 51 -- -- 0.04 0.03-0.04
Non-Malignant 490 98 -- 25.5 0.03 0.03-0.03 255 51 -- -- 0.03 0.03-0.04 235 47 -- -- 0.03 0.03-0.03
Tumors of Sellar Region 73,340 14,668 17.7% 51 4.39 4.36-4.43 33,190 6,638 0.3% 99.7% 4.02 3.98-4.07 40,150 8,030 0.1% 99.9% 4.85 4.80-4.90
Tumors of the Pituitary 70,211 14,042 16.9% 51 4.20 4.17-4.23 31,611 6,322 0.3% 99.7% 3.82 3.78-3.87 38,600 7,720 0.1% 99.9% 4.66 4.61-4.71
Malignant 142 28 -- 57 0.01 0.01-0.01 86 17 -- -- 0.01 0.01-0.01 56 11 -- -- 0.01 0.00-0.01
Non-Malignant 70,069 14,014 -- 51 4.19 4.16-4.22 31,525 6,305 -- -- 3.81 3.77-3.86 38,544 7,709 -- -- 4.65 4.61-4.70
Craniopharyngioma 3,129 626 0.8% 44 0.19 0.19-0.20 1,579 316 0.6% 99.4% 0.20 0.19-0.21 1,550 310 0.3% 99.7% 0.19 0.18-0.20
Unclassified Tumors 20,061 4,012 4.8% 64 1.16 1.14-1.17 9,087 1,817 34.9% 65.1% 1.15 1.12-1.17 10,974 2,195 31.8% 68.2% 1.18 1.15-1.20
Hemangioma 5,731 1,146 1.4% 50 0.34 0.34-0.35 2,518 504 0.4% 99.6% 0.31 0.30-0.33 3,213 643 0.4% 99.6% 0.38 0.36-0.39
Neoplasm Unspecified 14,136 2,827 3.4% 70 0.80 0.79-0.82 6,451 1,290 48.6% 51.4% 0.82 0.80-0.84 7,685 1,537 44.9% 55.1% 0.79 0.77-0.81
Malignant 6,587 1,317 -- 76 0.36 0.35-0.37 3,135 627 -- -- 0.40 0.39-0.41 3,452 690 -- -- 0.33 0.32-0.35
Non-Malignant 7,549 1,510 -- 63 0.44 0.43-0.45 3,316 663 -- -- 0.42 0.41-0.44 4,233 847 -- -- 0.46 0.44-0.47
All Other 194 39 0.0% 66 0.01 0.01-0.01 118 24 20.3% 79.7% 0.02 0.01-0.02 76 15 31.6% 68.4% 0.01 0.01-0.01
TOTAL c 415,411 83,082 -- 60 23.79 23.71-23.86 173,641 34,728 39.5% 60.5% 21.09 20.99-21.20 241,770 48,354 22.7% 77.3% 26.31 26.21-26.42
Malignant 123,484 24,697 29.7% 60 7.08 7.04-7.12 68,578 13,716 -- -- 8.30 8.24-8.36 54,906 10,981 -- -- 6.01 5.95-6.06
Non-Malignant 291,927 58,385 70.3% 61 16.71 16.64-16.77 105,063 21,013 -- -- 12.80 12.72-12.88 186,864 37,373 -- -- 20.31 20.21-20.40

a. Annual average cases are calculated by dividing the five-year total by five.

b. Rates are per 100,000 and are age-adjusted to the 2000 US standard population.

c. Refers to all brain tumors including histologies not presented in this table.

-- Counts and rates are not presented when fewer than 20 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.

Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified