Table 5.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals of Brain and Other Central Nervous System Tumors by Major Histology Grouping, Histology, and NCI Age Group, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2013-2017
| Histology | Age at Diagnosis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Childrenc (0-14) Years | AYAd (15-39) Years | Adults (40+) Years | ||||||||||
| 5-Year Total | Annual Average | Rate | 95% CI | 5-Year Total | Annual Average | Rate | 95% CI | 5-Year Total | Annual Average | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 12,719 | 2,544 | 4.19 | 4.12-4.26 | 18,350 | 3,670 | 3.46 | 3.41-3.52 | 81,987 | 16,397 | 10.30 | 10.23-10.37 |
| Pilocytic Astrocytoma | 3,128 | 626 | 1.03 | 0.99-1.07 | 1,460 | 292 | 0.27 | 0.26-0.29 | 579 | 116 | 0.08 | 0.07-0.09 |
| Diffuse Astrocytoma | 703 | 141 | 0.23 | 0.21-0.25 | 2,392 | 478 | 0.45 | 0.43-0.47 | 4,333 | 867 | 0.57 | 0.55-0.58 |
| Anaplastic Astrocytoma | 283 | 57 | 0.09 | 0.08-0.11 | 1,858 | 372 | 0.35 | 0.34-0.37 | 4,975 | 995 | 0.64 | 0.62-0.66 |
| Unique Astrocytoma Variants | 379 | 76 | 0.13 | 0.11-0.14 | 387 | 77 | 0.07 | 0.06-0.08 | 357 | 71 | 0.05 | 0.04-0.05 |
| Malignant | 158 | 32 | 0.05 | 0.04-0.06 | 289 | 58 | 0.05 | 0.05-0.06 | 322 | 64 | 0.04 | 0.04-0.05 |
| Non-Malignant | 221 | 44 | 0.07 | 0.06-0.08 | 98 | 20 | 0.02 | 0.01-0.02 | 35 | 7 | 0.00 | 0.00-0.01 |
| Glioblastoma | 480 | 96 | 0.16 | 0.14-0.17 | 2,767 | 553 | 0.54 | 0.52-0.56 | 56,809 | 11,362 | 6.97 | 6.91-7.03 |
| Oligodendroglioma | 86 | 17 | 0.03 | 0.02-0.04 | 1,431 | 286 | 0.27 | 0.26-0.29 | 2,181 | 436 | 0.30 | 0.29-0.32 |
| Anaplastic Oligodendroglioma | -- | -- | -- | -- | -- | -- | -- | -- | 1,346 | 269 | 0.18 | 0.17-0.19 |
| Oligoastrocytic Tumors | 38 | 8 | 0.01 | 0.01-0.02 | 643 | 129 | 0.12 | 0.11-0.13 | 891 | 178 | 0.12 | 0.11-0.13 |
| Ependymal Tumors | 959 | 192 | 0.32 | 0.30-0.34 | 1,893 | 379 | 0.36 | 0.34-0.38 | 3,991 | 798 | 0.53 | 0.51-0.55 |
| Malignant | 845 | 169 | 0.28 | 0.26-0.30 | 1,033 | 207 | 0.20 | 0.18-0.21 | 2,094 | 419 | 0.28 | 0.26-0.29 |
| Non-Malignant | 114 | 23 | 0.04 | 0.03-0.05 | 860 | 172 | 0.16 | 0.15-0.17 | 1,897 | 379 | 0.25 | 0.24-0.26 |
| Glioma Malignant, NOS | 2,558 | 512 | 0.84 | 0.81-0.88 | 1,662 | 332 | 0.31 | 0.30-0.33 | 3,873 | 775 | 0.50 | 0.49-0.52 |
| Choroid Plexus Tumors | 365 | 73 | 0.12 | 0.11-0.13 | 216 | 43 | 0.04 | 0.04-0.05 | 246 | 49 | 0.03 | 0.03-0.04 |
| Malignant | 101 | 20 | 0.03 | 0.03-0.04 | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 264 | 53 | 0.09 | 0.08-0.10 | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Neuroepithelial Tumors | 25 | 5 | 0.01 | 0.01-0.01 | 36 | 7 | 0.01 | 0.00-0.01 | 46 | 9 | 0.01 | 0.00-0.01 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | 22 | 4 | 0.00 | 0.00-0.00 |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | 24 | 5 | 0.00 | 0.00-0.00 |
| Neuronal and Mixed Neuronal Glial Tumors | 1,298 | 260 | 0.43 | 0.41-0.45 | 1,981 | 396 | 0.37 | 0.35-0.38 | 1,655 | 331 | 0.22 | 0.21-0.23 |
| Malignant | 70 | 14 | 0.02 | 0.02-0.03 | 199 | 40 | 0.04 | 0.03-0.04 | 678 | 136 | 0.09 | 0.08-0.09 |
| Non-Malignant | 1,228 | 246 | 0.41 | 0.38-0.43 | 1,782 | 356 | 0.33 | 0.32-0.35 | 977 | 195 | 0.14 | 0.13-0.14 |
| Tumors of the Pineal Region | 153 | 31 | 0.05 | 0.04-0.06 | 289 | 58 | 0.05 | 0.05-0.06 | 345 | 69 | 0.05 | 0.04-0.05 |
| Malignant | 133 | 27 | 0.04 | 0.04-0.05 | 162 | 32 | 0.03 | 0.03-0.03 | 152 | 30 | 0.02 | 0.02-0.02 |
| Non-Malignant | 20 | 4 | 0.01 | 0.00-0.01 | 127 | 25 | 0.02 | 0.02-0.03 | 193 | 39 | 0.03 | 0.02-0.03 |
| Embryonal Tumors | 2,252 | 450 | 0.74 | 0.71-0.77 | 834 | 167 | 0.15 | 0.14-0.16 | 360 | 72 | 0.05 | 0.04-0.06 |
| Medulloblastoma | 1,463 | 293 | 0.48 | 0.46-0.51 | 632 | 126 | 0.12 | 0.11-0.13 | 155 | 31 | 0.02 | 0.02-0.03 |
| Primitive neuroectodermal tumors | 214 | 43 | 0.07 | 0.06-0.08 | 102 | 20 | 0.02 | 0.02-0.02 | 111 | 22 | 0.01 | 0.01-0.02 |
| Atypical teratoid rhabdoid tumor | 374 | 75 | 0.12 | 0.11-0.14 | 28 | 6 | 0.01 | 0.00-0.01 | -- | -- | -- | -- |
| Other embryonal histologies | 201 | 40 | 0.07 | 0.06-0.08 | 72 | 14 | 0.01 | 0.01-0.02 | 81 | 16 | 0.01 | 0.01-0.01 |
| Tumors of Cranial and Spinal Nerves | 840 | 168 | 0.28 | 0.26-0.30 | 5,430 | 1,086 | 1.05 | 1.02-1.08 | 29,330 | 5,866 | 3.72 | 3.67-3.76 |
| Nerve Sheath Tumors | 840 | 168 | 0.28 | 0.26-0.30 | 5,422 | 1,084 | 1.05 | 1.02-1.08 | 29,298 | 5,860 | 3.71 | 3.67-3.76 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Tumors of Cranial and Spinal Nerves | -- | -- | -- | -- | -- | -- | -- | -- | 32 | 6 | 0.00 | 0.00-0.01 |
| Tumors of Meninges | 592 | 118 | 0.20 | 0.18-0.21 | 10,765 | 2,153 | 2.14 | 2.09-2.18 | 152,262 | 30,452 | 19.26 | 19.16-19.36 |
| Meningioma | 306 | 61 | 0.10 | 0.09-0.11 | 9,438 | 1,888 | 1.89 | 1.85-1.92 | 149,294 | 29,859 | 18.88 | 18.78-18.97 |
| Malignant | 22 | 4 | 0.01 | 0.00-0.01 | 122 | 24 | 0.02 | 0.02-0.03 | 1,606 | 321 | 0.20 | 0.19-0.21 |
| Non-Malignant | 284 | 57 | 0.09 | 0.08-0.11 | 9,316 | 1,863 | 1.86 | 1.82-1.90 | 147,688 | 29,538 | 18.68 | 18.58-18.77 |
| Mesenchymal Tumors | 223 | 45 | 0.07 | 0.06-0.08 | 334 | 67 | 0.06 | 0.06-0.07 | 905 | 181 | 0.12 | 0.11-0.13 |
| Primary Melanocytic Lesions | -- | -- | -- | -- | -- | -- | -- | -- | 85 | 17 | 0.01 | 0.01-0.01 |
| Other Neoplasms Related to the Meninges | 55 | 11 | 0.02 | 0.01-0.02 | 978 | 196 | 0.18 | 0.17-0.20 | 1,978 | 396 | 0.26 | 0.25-0.27 |
| Lymphoma and Hematopoietic Neoplasms | 78 | 16 | 0.03 | 0.02-0.03 | 548 | 110 | 0.11 | 0.10-0.11 | 7,524 | 1,505 | 0.94 | 0.92-0.96 |
| Lymphoma | 29 | 6 | 0.01 | 0.01-0.01 | 491 | 98 | 0.09 | 0.09-0.10 | 7,399 | 1,480 | 0.93 | 0.90-0.95 |
| Other Hematopoietic Neoplasms | 49 | 10 | 0.02 | 0.01-0.02 | 57 | 11 | 0.01 | 0.01-0.01 | 125 | 25 | 0.02 | 0.01-0.02 |
| Germ Cell Tumors and Cysts | 694 | 139 | 0.23 | 0.21-0.25 | 700 | 140 | 0.13 | 0.12-0.14 | 191 | 38 | 0.03 | 0.02-0.03 |
| Germ Cell Tumors, Cysts and Heterotopias | 694 | 139 | 0.23 | 0.21-0.25 | 700 | 140 | 0.13 | 0.12-0.14 | 191 | 38 | 0.03 | 0.02-0.03 |
| Malignant | 508 | 102 | 0.17 | 0.15-0.18 | 558 | 112 | 0.10 | 0.09-0.11 | 29 | 6 | 0.00 | 0.00-0.01 |
| Non-Malignant | 186 | 37 | 0.06 | 0.05-0.07 | 142 | 28 | 0.03 | 0.02-0.03 | 162 | 32 | 0.02 | 0.02-0.03 |
| Tumors of Sellar Region | 1,715 | 343 | 0.57 | 0.54-0.60 | 21,491 | 4,298 | 4.07 | 4.02-4.13 | 50,134 | 10,027 | 6.57 | 6.51-6.63 |
| Tumors of the Pituitary | 1,029 | 206 | 0.34 | 0.32-0.36 | 20,782 | 4,156 | 3.94 | 3.88-3.99 | 48,400 | 9,680 | 6.34 | 6.28-6.40 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Craniopharyngioma | 686 | 137 | 0.23 | 0.21-0.24 | 709 | 142 | 0.13 | 0.12-0.14 | 1,734 | 347 | 0.22 | 0.21-0.24 |
| Unclassified Tumors | 1,035 | 207 | 0.34 | 0.32-0.36 | 3,074 | 615 | 0.58 | 0.56-0.60 | 15,952 | 3,190 | 2.04 | 2.01-2.07 |
| Hemangioma | 374 | 75 | 0.12 | 0.11-0.14 | 1,506 | 301 | 0.29 | 0.27-0.30 | 3,851 | 770 | 0.50 | 0.49-0.52 |
| Neoplasm Unspecified | 628 | 126 | 0.21 | 0.19-0.22 | 1,548 | 310 | 0.29 | 0.28-0.31 | 11,960 | 2,392 | 1.52 | 1.49-1.55 |
| Malignant | 164 | 33 | 0.05 | 0.05-0.06 | 348 | 70 | 0.07 | 0.06-0.07 | 6,075 | 1,215 | 0.76 | 0.74-0.78 |
| Non-Malignant | 464 | 93 | 0.15 | 0.14-0.17 | 1,200 | 240 | 0.23 | 0.21-0.24 | 5,885 | 1,177 | 0.76 | 0.74-0.78 |
| All Other | 33 | 7 | 0.01 | 0.01-0.02 | 20 | 4 | 0.00 | 0.00-0.01 | 141 | 28 | 0.02 | 0.01-0.02 |
| TOTAL e | 17,673 | 3,535 | 5.83 | 5.74-5.91 | 60,358 | 12,072 | 11.54 | 11.45-11.63 | 337,380 | 67,476 | 42.85 | 42.71-43.00 |
| Malignant | 11,738 | 2,348 | 3.87 | 3.80-3.94 | 17,073 | 3,415 | 3.23 | 3.18-3.28 | 94,673 | 18,935 | 11.86 | 11.78-11.94 |
| Non-Malignant | 5,935 | 1,187 | 1.96 | 1.91-2.01 | 43,285 | 8,657 | 8.31 | 8.23-8.39 | 242,707 | 48,541 | 30.99 | 30.87-31.12 |
a. Annual average cases are calculated by dividing the five-year total by five.
b. Rates are per 100,000 and are age-adjusted to the 2000 US standard population.
c. Children as defined by the National Cancer Institute, see: http://www.cancer.gov/researchandfunding/snapshots/pediatric.
d. Adolescents and Young Adults (AYA), as defined by the National Cancer Institute, see: http://www.cancer.gov/cancertopics/aya.
e. Refers to all brain tumors including histologies not presented in this table.
-- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: AYA, Adolescents and Young Adults; CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified