Table 7.
Five-Year Total, Average Annual Age-Adjusted and Age-Specific Incidence Ratesa with 95% Confidence Intervals for Adults (Age 20+ Years), Brain and Other Central Nervous System Tumors by Major Histology Grouping, Histology, and Age at Diagnosis, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2013-2017
| Histology | Age At Diagnosis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 20-34 years | 35-44 years | 45-54 years | 55-64 years | 65-74 years | 75-84 years | 85+ years | ||||||||
| Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 3.34 | 3.27-3.40 | 4.47 | 4.37-4.56 | 6.71 | 6.61-6.82 | 11.30 | 11.16-11.45 | 16.79 | 16.57-17.01 | 19.26 | 18.93-19.59 | 12.03 | 11.65-12.42 |
| Pilocytic Astrocytoma | 0.21 | 0.20-0.23 | 0.13 | 0.11-0.14 | 0.09 | 0.08-0.11 | 0.07 | 0.06-0.08 | 0.07 | 0.05-0.08 | 0.05 | 0.04-0.07 | -- | -- |
| Diffuse Astrocytoma | 0.49 | 0.46-0.51 | 0.50 | 0.46-0.53 | 0.47 | 0.44-0.50 | 0.56 | 0.53-0.59 | 0.77 | 0.72-0.81 | 0.82 | 0.75-0.89 | 0.47 | 0.40-0.55 |
| Anaplastic Astrocytoma | 0.38 | 0.36-0.40 | 0.50 | 0.47-0.53 | 0.51 | 0.48-0.54 | 0.68 | 0.65-0.72 | 0.90 | 0.85-0.95 | 0.93 | 0.86-1.00 | 0.41 | 0.34-0.49 |
| Unique Astrocytoma Variants | 0.07 | 0.06-0.08 | 0.04 | 0.03-0.05 | 0.03 | 0.03-0.04 | 0.04 | 0.03-0.05 | 0.06 | 0.05-0.08 | 0.08 | 0.06-0.11 | 0.07 | 0.04-0.11 |
| Malignant | 0.05 | 0.04-0.06 | 0.04 | 0.03-0.04 | 0.03 | 0.02-0.03 | 0.04 | 0.03-0.05 | 0.06 | 0.05-0.07 | 0.08 | 0.06-0.11 | 0.07 | 0.04-0.10 |
| Non-Malignant | 0.02 | 0.01-0.02 | 0.01 | 0.00-0.01 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | -- | -- | -- | -- |
| Glioblastoma | 0.47 | 0.45-0.49 | 1.27 | 1.22-1.32 | 3.60 | 3.53-3.69 | 8.06 | 7.94-8.18 | 13.00 | 12.81-13.20 | 15.30 | 15.01-15.59 | 9.01 | 8.68-9.35 |
| Oligodendroglioma | 0.28 | 0.26-0.30 | 0.43 | 0.40-0.46 | 0.38 | 0.36-0.41 | 0.27 | 0.25-0.30 | 0.19 | 0.17-0.22 | 0.14 | 0.11-0.17 | 0.06 | 0.04-0.10 |
| Anaplastic Oligodendroglioma | 0.10 | 0.09-0.11 | 0.18 | 0.17-0.20 | 0.21 | 0.19-0.23 | 0.19 | 0.18-0.21 | 0.16 | 0.14-0.18 | 0.12 | 0.09-0.14 | -- | -- |
| Oligoastrocytic Tumors | 0.14 | 0.12-0.15 | 0.17 | 0.15-0.19 | 0.14 | 0.12-0.15 | 0.11 | 0.10-0.13 | 0.11 | 0.09-0.13 | 0.07 | 0.05-0.09 | -- | -- |
| Ependymal Tumors | 0.35 | 0.33-0.37 | 0.52 | 0.49-0.55 | 0.55 | 0.52-0.59 | 0.56 | 0.53-0.60 | 0.60 | 0.56-0.64 | 0.40 | 0.36-0.45 | 0.12 | 0.08-0.16 |
| Malignant | 0.18 | 0.17-0.20 | 0.27 | 0.25-0.29 | 0.29 | 0.27-0.31 | 0.30 | 0.28-0.32 | 0.32 | 0.29-0.35 | 0.23 | 0.19-0.26 | 0.06 | 0.04-0.10 |
| Non-Malignant | 0.17 | 0.15-0.18 | 0.25 | 0.23-0.27 | 0.27 | 0.25-0.29 | 0.26 | 0.24-0.29 | 0.28 | 0.25-0.31 | 0.18 | 0.15-0.21 | 0.05 | 0.03-0.09 |
| Glioma Malignant, NOS | 0.29 | 0.27-0.31 | 0.28 | 0.25-0.30 | 0.33 | 0.31-0.36 | 0.39 | 0.37-0.42 | 0.60 | 0.56-0.64 | 1.08 | 1.00-1.16 | 1.70 | 1.56-1.86 |
| Choroid Plexus Tumors | 0.04 | 0.03-0.05 | 0.04 | 0.03-0.05 | 0.03 | 0.02-0.03 | 0.04 | 0.03-0.05 | 0.03 | 0.02-0.04 | 0.04 | 0.03-0.06 | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Neuroepithelial Tumors | 0.01 | 0.00-0.01 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Neuronal and Mixed Neuronal Glial Tumors | 0.33 | 0.31-0.35 | 0.26 | 0.24-0.28 | 0.25 | 0.23-0.27 | 0.22 | 0.20-0.24 | 0.21 | 0.19-0.24 | 0.16 | 0.14-0.20 | 0.08 | 0.05-0.12 |
| Malignant | 0.03 | 0.03-0.04 | 0.06 | 0.05-0.07 | 0.08 | 0.07-0.10 | 0.10 | 0.08-0.11 | 0.11 | 0.09-0.13 | 0.10 | 0.07-0.12 | 0.07 | 0.04-0.10 |
| Non-Malignant | 0.29 | 0.27-0.31 | 0.20 | 0.18-0.22 | 0.17 | 0.15-0.18 | 0.12 | 0.11-0.14 | 0.10 | 0.09-0.12 | 0.07 | 0.05-0.09 | -- | -- |
| Tumors of the Pineal Region | 0.06 | 0.05-0.06 | 0.05 | 0.04-0.06 | 0.05 | 0.04-0.06 | 0.04 | 0.04-0.05 | 0.05 | 0.04-0.06 | 0.02 | 0.01-0.04 | -- | -- |
| Malignant | 0.03 | 0.03-0.04 | 0.02 | 0.02-0.03 | 0.03 | 0.02-0.03 | 0.02 | 0.01-0.03 | 0.02 | 0.01-0.03 | -- | -- | -- | -- |
| Non-Malignant | 0.03 | 0.02-0.03 | 0.03 | 0.02-0.04 | 0.03 | 0.02-0.03 | 0.02 | 0.02-0.03 | 0.03 | 0.02-0.04 | -- | -- | -- | -- |
| Embryonal Tumors | 0.15 | 0.14-0.16 | 0.09 | 0.08-0.10 | 0.05 | 0.04-0.06 | 0.05 | 0.04-0.06 | 0.03 | 0.02-0.04 | 0.04 | 0.03-0.06 | -- | -- |
| Tumors of Cranial and Spinal Nerves | 0.95 | 0.91-0.98 | 2.15 | 2.08-2.21 | 3.27 | 3.19-3.35 | 4.49 | 4.40-4.58 | 5.33 | 5.20-5.45 | 4.20 | 4.04-4.35 | 1.85 | 1.70-2.00 |
| Nerve Sheath Tumors | 0.94 | 0.91-0.98 | 2.14 | 2.08-2.21 | 3.27 | 3.19-3.34 | 4.49 | 4.39-4.58 | 5.32 | 5.20-5.44 | 4.19 | 4.04-4.35 | 1.85 | 1.70-2.00 |
| Malignant | 0.01 | 0.01-0.01 | 0.02 | 0.01-0.02 | 0.02 | 0.01-0.03 | 0.02 | 0.01-0.02 | 0.04 | 0.03-0.05 | 0.02 | 0.01-0.04 | -- | -- |
| Non-Malignant | 0.94 | 0.90-0.97 | 2.13 | 2.06-2.19 | 3.25 | 3.17-3.32 | 4.47 | 4.38-4.56 | 5.28 | 5.16-5.41 | 4.17 | 4.02-4.33 | 1.82 | 1.67-1.98 |
| Other Tumors of Cranial and Spinal Nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 1.71 | 1.67-1.76 | 5.81 | 5.70-5.91 | 10.92 | 10.78-11.06 | 16.93 | 16.75-17.11 | 29.54 | 29.25-29.84 | 43.77 | 43.28-44.26 | 55.23 | 54.41-56.06 |
| Meningioma | 1.46 | 1.42-1.50 | 5.49 | 5.39-5.60 | 10.55 | 10.41-10.68 | 16.51 | 16.33-16.68 | 29.08 | 28.79-29.37 | 43.33 | 42.84-43.82 | 55.08 | 54.26-55.91 |
| Malignant | 0.02 | 0.02-0.03 | 0.05 | 0.04-0.06 | 0.10 | 0.09-0.12 | 0.21 | 0.19-0.23 | 0.33 | 0.30-0.36 | 0.44 | 0.39-0.49 | 0.49 | 0.42-0.57 |
| Non-Malignant | 1.44 | 1.40-1.48 | 5.44 | 5.34-5.54 | 10.45 | 10.31-10.58 | 16.30 | 16.12-16.47 | 28.75 | 28.46-29.04 | 42.89 | 42.41-43.38 | 54.59 | 53.77-55.42 |
| Mesenchymal Tumors | 0.06 | 0.05-0.07 | 0.08 | 0.07-0.10 | 0.12 | 0.10-0.13 | 0.13 | 0.11-0.14 | 0.14 | 0.12-0.16 | 0.15 | 0.12-0.18 | 0.07 | 0.04-0.10 |
| Primary Melanocytic Lesions | -- | -- | -- | -- | 0.01 | 0.00-0.01 | 0.02 | 0.01-0.02 | 0.01 | 0.01-0.02 | -- | -- | -- | -- |
| Other Neoplasms Related to the Meninges | 0.19 | 0.17-0.20 | 0.22 | 0.20-0.25 | 0.25 | 0.23-0.27 | 0.28 | 0.26-0.31 | 0.31 | 0.28-0.34 | 0.27 | 0.23-0.31 | 0.07 | 0.05-0.11 |
| Lymphomas and Hematopoietic Neoplasms | 0.10 | 0.09-0.11 | 0.21 | 0.19-0.23 | 0.41 | 0.38-0.43 | 0.89 | 0.85-0.93 | 1.87 | 1.80-1.95 | 2.43 | 2.31-2.55 | 1.26 | 1.14-1.39 |
| Lymphoma | 0.09 | 0.08-0.10 | 0.20 | 0.18-0.22 | 0.39 | 0.37-0.42 | 0.88 | 0.83-0.92 | 1.85 | 1.77-1.92 | 2.41 | 2.29-2.53 | 1.24 | 1.12-1.37 |
| Other Hematopoietic Neoplasms | 0.01 | 0.01-0.01 | 0.01 | 0.01-0.02 | 0.01 | 0.01-0.02 | 0.02 | 0.01-0.02 | 0.03 | 0.02-0.04 | -- | -- | -- | -- |
| Germ Cell Tumors and Cysts | 0.11 | 0.10-0.12 | 0.03 | 0.03-0.04 | 0.03 | 0.02-0.03 | 0.02 | 0.02-0.03 | 0.02 | 0.02-0.03 | -- | -- | -- | -- |
| Germ Cell Tumors, Cysts and Heterotopias | 0.11 | 0.10-0.12 | 0.03 | 0.03-0.04 | 0.03 | 0.02-0.03 | 0.02 | 0.02-0.03 | 0.02 | 0.02-0.03 | -- | -- | -- | -- |
| Malignant | 0.08 | 0.07-0.09 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 0.03 | 0.02-0.03 | 0.03 | 0.02-0.03 | 0.02 | 0.02-0.03 | 0.02 | 0.01-0.03 | 0.02 | 0.01-0.03 | -- | -- | -- | -- |
| Tumors of Sellar Region | 4.05 | 3.99-4.12 | 5.64 | 5.53-5.74 | 5.71 | 5.61-5.81 | 6.58 | 6.47-6.69 | 8.35 | 8.19-8.50 | 8.54 | 8.33-8.76 | 5.31 | 5.06-5.58 |
| Tumors of the Pituitary | 3.94 | 3.87-4.01 | 5.46 | 5.36-5.56 | 5.50 | 5.40-5.60 | 6.32 | 6.21-6.43 | 8.07 | 7.92-8.22 | 8.33 | 8.11-8.54 | 5.23 | 4.98-5.49 |
| Malignant | -- | -- | 0.01 | 0.01-0.02 | 0.01 | 0.01-0.02 | 0.02 | 0.01-0.03 | 0.02 | 0.01-0.02 | 0.02 | 0.01-0.04 | -- | -- |
| Non-Malignant | 3.94 | 3.87-4.01 | 5.45 | 5.35-5.55 | 5.48 | 5.38-5.58 | 6.30 | 6.19-6.41 | 8.05 | 7.90-8.21 | 8.30 | 8.09-8.52 | 5.23 | 4.98-5.49 |
| Craniopharyngioma | 0.11 | 0.10-0.13 | 0.18 | 0.16-0.20 | 0.21 | 0.19-0.23 | 0.26 | 0.24-0.29 | 0.28 | 0.25-0.31 | 0.22 | 0.18-0.25 | 0.08 | 0.05-0.12 |
| Unclassified Tumors | 0.56 | 0.53-0.59 | 0.82 | 0.78-0.86 | 1.07 | 1.02-1.11 | 1.46 | 1.41-1.51 | 2.39 | 2.31-2.47 | 4.74 | 4.58-4.91 | 10.56 | 10.20-10.93 |
| Hemangioma | 0.28 | 0.26-0.30 | 0.40 | 0.37-0.43 | 0.45 | 0.42-0.48 | 0.51 | 0.48-0.55 | 0.59 | 0.55-0.63 | 0.66 | 0.60-0.72 | 0.49 | 0.42-0.58 |
| Neoplasm Unspecified | 0.28 | 0.26-0.30 | 0.42 | 0.39-0.45 | 0.61 | 0.58-0.65 | 0.93 | 0.89-0.98 | 1.77 | 1.70-1.84 | 4.03 | 3.89-4.18 | 9.98 | 9.63-10.34 |
| Malignant | 0.06 | 0.05-0.07 | 0.11 | 0.09-0.12 | 0.20 | 0.18-0.22 | 0.42 | 0.40-0.45 | 0.88 | 0.83-0.93 | 2.29 | 2.18-2.40 | 6.05 | 5.78-6.33 |
| Non-Malignant | 0.22 | 0.20-0.23 | 0.31 | 0.29-0.34 | 0.41 | 0.38-0.44 | 0.51 | 0.48-0.54 | 0.89 | 0.84-0.94 | 1.75 | 1.65-1.85 | 3.93 | 3.71-4.15 |
| All Other | -- | -- | -- | -- | -- | -- | 0.01 | 0.01-0.01 | 0.03 | 0.02-0.04 | 0.05 | 0.04-0.07 | 0.09 | 0.06-0.13 |
| TOTAL b | 10.82 | 10.70-10.93 | 19.12 | 18.93-19.32 | 28.11 | 27.89-28.34 | 41.68 | 41.40-41.96 | 64.29 | 63.86-64.73 | 82.96 | 82.28-83.64 | 86.27 | 85.24-87.31 |
| Malignant | 3.10 | 3.04-3.16 | 4.39 | 4.30-4.48 | 7.03 | 6.91-7.14 | 12.49 | 12.34-12.65 | 19.56 | 19.33-19.80 | 24.25 | 23.88-24.62 | 19.81 | 19.32-20.31 |
| Non-Malignant | 7.72 | 7.62-7.81 | 14.74 | 14.57-14.90 | 21.08 | 20.89-21.28 | 29.19 | 28.95-29.42 | 44.73 | 44.37-45.09 | 58.71 | 58.14-59.28 | 66.46 | 65.56-67.38 |
a. Rates are per 100,000 and age-adjusted to the 2000 US standard population.
b. Refers to all brain tumors including histologies not presented in this table.
- Counts and rates are not presented when fewer than 20 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified