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. 2020 Jul 10;11(1):77–98. doi: 10.1016/j.jcmgh.2020.07.003

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Muc2^–/–FMT increases susceptibility to DSS-induced colitis in Muc2^+/+littermates. (A) Antibiotic treated Muc2^+/+ receiving Muc2^–/– FMT showed increased mortality to DSS induced colitis and the surviving animals did not recover weight up to day 14. (B) Muc2^–/– mice receiving Muc2^+/+ FMT showed less severe illness and no mortality in response to DSS induced colitis. (C) Muc2^+/+ mice receiving Muc2^–/– FMT showed an increased in DAI compared with those who received their own. (D) On day 14, Muc2^+/+ receiving Muc2^–/– FMT showed increased intestinal permeability as compared with Muc2^+/+ receiving their own microbiota. (E) Survival and body weight change of Muc2^+/+ and Muc2^–/– bone marrow (BM) chimeras challenged with DSS. n = 4–6, ∗P < .05, ∗∗P < .01, BW, body weight.