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. 2020 Jul 10;11(1):77–98. doi: 10.1016/j.jcmgh.2020.07.003

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Muc2^–/–microbiota transplanted to Muc2^+/+littermates. (A) Dissimilarity measured by nonmetric multidimensional scaling (NMDS) illustrates the distance throughout samples that were antibiotic-treated and FMT with Muc2^–/– and Muc2^+/+ microbiota. Time points are as follow: day –17: before antibiotic treatment, days 1, 5, and 10 correspond to days passed after the last FMT; (a) Muc2^–/– FMT with Muc2^+/+, (b) Muc2^+/+ FMT with Muc2^+/+, (c) Muc2^–/– FMT with Muc2^–/–, and (d) Muc2^+/+ FMT with Muc2^–/–. (B) Significantly different OTUs between Muc2^+/+ FMT with Muc2^–/– and Muc2^+/+ were grouped by family and the top 5 plotted in a bar graph to illustrate their difference in abundance. Plots C–G display the 5 families’ dynamics at different time points.