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Oxidation of ETE and ETE-PE by 15LOX2 and 15LOX2/PEBP1 complex. a) Effect of Fer-1 on ETE oxidation by 15LOX2 and 15LOX2/PEBP1; b) Oxidation of ETE-PE by 15LOX2 and 15LOX2/PEBP1; c) Inhibition of 15LOX2 and 15LOX2/PEBP1 catalyzed ETE-PE oxidation by Fer-1. The IC50 = 10.1 nM (for 15LOX2/PEBP1; two-way ANOVA with Sidak test).
