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. 2020 Oct 16;38:101744. doi: 10.1016/j.redox.2020.101744

Scheme 1.

Scheme 1

Two alternative oxidation mechanisms: enzymatic (15LOX/PEBP1-driven) and/or non-enzymatic (Fe-driven) reactions of phospholipids (PL) (with the allyl hydrogen shown explicitly as PLH) oxidation yielding hydroperoxy-phospholipids (PLOOH) and their inhibition by ferrostatin-1 (Fer-1).

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