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. 2020 Oct 31;56:58–68. doi: 10.1540/jsmr.56.58

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©2020 The Japan Society of Smooth Muscle Research

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1. — Musculature of the stomach and small intestine of BALB/c and W^sh/W^sh mice.

ICC were detected using immunofluorescence, showing TMEM16A immunoreactivity (green) and c-Kit ACK4 immunoreactivity (red) in both BALB/c (A, C, E) and W^sh/W^sh (B, D, F) mice. In the fundus (A, B), ICC-IM were observed in the musculature only in BALB/c mice. In the corpus (C, D), BALB/c mice have ICC-MY (arrows) and ICC-IM. Contrastingly, W^sh/W^sh mice have only ICC-MY (arrows) that were confirmed through TMEM16A immunoreactivity. In the small intestine (E, F), BALB/c mice have ICC-DMP (arrowheads) and ICC-MY (arrows) with TMEM16A (green) and c-Kit (red) immunoreactivities, whereas W^sh/W^sh mice have TMEM16A immunopositive ICC-DMP (arrowheads) in the circular muscle. c and l represent circular and longitudinal muscle layers, respectively. Asterisks show myenteric layer. Bar: 50 μm.