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. 2020 Oct 16;11:929. doi: 10.3389/fgene.2020.00929

Figure 1.

Figure 1

The expression of colon cancer-associated transcript-1(CCAT1) was negatively related to the miR-219-1 expression. (A) Relative CCAT1 expression in human lung adenocarcinoma (LAD) and adjacent non-tumor tissues. (B) Relative miR-219-1 expression in human LAD and adjacent normal tissues. (C) An inverse correlation between CCAT1 and miR-219-1 expressions in LAD tissue samples. (D) Bioinformatics analysis was performed to identify miR-219-1 binding sites in CCAT1. (E) A luciferase reporter assay was used to examine the relationship between CCAT1 and miR-219-1. (F,G) Relative miR-219-1 expression in A549 and H1299 cells transfected with CCAT1 shRNA and CCAT1 shRNA-2. (H,I) Cell viability of A549 and H1299 transfected with CCAT1 shRNA and CCAT1 shRNA-2. (J) Relative miR-219-1 expression in A549 and H1299 transfected with the miR-219-1 mimic and NC. (K,L) Cell viability of A549 and H1299 transfected with the miR-219-1 mimic and NC. (M) Relative miR-219-1 expression in A549 and H1299 transfected with the miR-219-1 inhibitor and NC. (N,O) Cell viability of A549 and H1299 transfected with the miR-219-1 inhibitor and NC. Data are shown as means ± SD. *p < 0.05.