Table 1.
General description from the 15 studies meeting inclusion criteria.
| Study | Location | Diagnostic criteria | Main findings |
|---|---|---|---|
| Paquet et al. (21) | France | NINCDS-ADRDA (22) | MCI showed thinner average pRNFL thickness compared with normal controls. |
| Kesler et al. (23) | Israel | Petersen Criteria (24) | MCI showed significantly thinner average pRNFL thickness compared with controls and a significant difference in the inferior quadrant thickness. |
| Shen et al. (25) | China | Petersen Criteria (24) | MCI showed significantly thinner inferior and nasal pRNFL quadrants but no difference in average pRNFL compared with controls. No significant difference in macula central thickness and macular volume thickness found between MCI and controls. |
| Ascaso et al. (26) | Spain | Winbald (27) | MCI showed a significant reduction in average pRNFL thickness and in all quadrants compared with age-matched controls. |
| Oktem et al. (28) | Turkey | Not mentioned | MCI showed significantly reduced average pRNFL thickness compared with the controls. |
| Liu et al. (29) | China | Petersen Criteria (24) | MCI showed significantly reduced average pRNFL and superior quadrant thickness compared with controls. |
| Gao et al. (30) | China | Petersen Criteria (24) | MCI had significantly decreased macular volume when adjusted for age and sex compared with controls. No significant difference was noted for the overall pRNFL. |
| Cheung et al. (31) | Singapore | Petersen Criteria (24) | MCI had significantly reduced mGCL-IPL thickness in all but the superior temporal sector compared with healthy controls. pRNFL thickness measures were not different between MCI compared with healthy controls. |
| Pillai et al. (32) | USA | NIA-AA (33) | MCI and controls had no significant differences in average pRNFL thickness, macular volume, or mGCL-IPL thickness. |
| Giménez Castejón et al. (34) | Spain | Neurological examination and DSM-IV (35) | MCI had significantly decreased total macular thickness compared with controls. |
| Ferrari et al. (36) | Italy | NIA-AA (33) | MCI had significant thinning of the average pRNFL compared with controls. There was no difference in pGCL-IPL thickness. |
| Uchida et al. (37) | USA | NIA-AA (33) | MCI showed no significant differences between MCI and controls in measurements of macular outer layers or the total macular thickness. |
| Shao et al. (38) | USA | NIA-AA (33) | MCI had significantly decreased total macular thickness and mGCL-IPL thickness in the superior and nasal quadrants compared with controls. |
| Lad et al. (39) | USA | NINCDS-ADRD (22) | MCI had no significant differences in average mRNFL thickness, mGCL-IPL compared with controls. |
| Almeida et al. (40) | Brazil | Collie (41) | MCI had no significant difference in pRNFL thickness compared with controls. Total macular thickness was decreased in MCI vs. control. |
MCI, mild cognitive impairment; RNFL, retinal nerve fiber layer; AD Alzheimer's disease; GCL-IPL, ganglion cell-inner plexiform layer; NINCDS-ADRD, National Institute of Neurological Disorders and Stroke-Alzheimer Disease and Related Disorders Association; NIA-AA, National Institutes of Health-Alzheimer's Association.
Results of this study are reported as the change in cell layers, not individual values are reported.