Table 2.
OCT retinal thickness measures from the 15 studies meeting inclusion criteria.
| Study | Subjects, n | Age, mean (SD) | Gender, Female (%) | Notes | Retinal scan location | OCT technique | Macular thickness μm, mean (SD) MCI | Macular thickness μm, mean (SD) NC | Macular volume μm, mean (SD) MCI | Macular volume μm, mean (SD) NC | pRNFL thickness μm, mean (SD) MCI | pRNFL thickness μm, mean (SD) NC | GC-IPL thickness μm, mean (SD) MCI | GC-IPL thickness μm, mean (SD) NC | mRNFL thickness in μm, mean (SD) MCI | mRNFL thickness in μm, mean (SD) NC | Outer Retinal Layers μm, mean (SD) MCI | Outer Retinal Layers μm, mean (SD) NC | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCI | NC | MCI | NC | MCI | NC | ||||||||||||||||
| Paquet et al. (21) | 23 | 15 | 78.7 (6.2) | 75.5 (5.1) | 65.2 | 86.6 | NA | CP | TD | ND | ND | ND | ND | 89.3 (2.7)* | 102.2 (1.8) | ND | ND | ND | ND | ND | ND |
| Kesler et al. (23) | 24 | 24 | 71.0 (10.0) | 70.9 (9.2) | NR | NR | NA | CP | TD | ND | ND | ND | ND | 85.8 (10.0)* | 94.3 (11.3) | ND | ND | ND | ND | ND | ND |
| Shen et al. (25) | 23 | 52 | 74.1 | 74.1 | 43.5 | 59.6 | NA | B | TD | VNR | VNR | VNR | VNR | Average 82.6 (10.5); Inferior: 104.5 (17.6)*; nasal 61.5 (8.1)* |
Average 85.6 (10.2); inferior 109.3 (21.3); nasal 64.8 (8.4) | ND | ND | ND | ND | ND | NR |
| Ascaso et al. (26) | 21 | 41 | NR | 72.9 | NR | 51,2 | NA | B | TD | OD: 228.19 (24.63) | OD: 208.66 (24.70) | OD: 7.06 (0.15) | OD: 6.51 (0.40) | OD: 86.03 (7.26)* | OD: 103.57 (8.94) | ND | ND | ND | ND | ND | ND |
| OS: 224.24 (23.34) | OS: 209.96 (22.04) | OS: 6.97 (0.48) | OS: 6.59 (0.38) | OS: 87.28 (7.22) * | OS: 102.65 (6.89) | ||||||||||||||||
| Oktem et al. (28) | 35 | 35 | 74.1 (6.3) | 70.2 (8.0) | 57.1 | 65.7 | NA | CP | SD | ND | ND | ND | ND | 82.5 (7.3)* | 91.5 (7.1) | ND | ND | ND | ND | ND | ND |
| Liu D et al. (29) | 26 | 39 | 71.3 (4.9) | 69.7 (7.8) | 62.5 | 56.4 | NA | CP | TD | ND | ND | ND | ND | 95.37 (17.11)* | 100.12 (15.01) | ND | ND | ND | ND | ND | ND |
| Gao et al. (30) | 26 | 21 | 73.42 (1.54) | 72.05 (1.02) | 38.5 | 66.6 | NA | B | SD | ND | ND | 9.63 (0.08) * | 9.96 (0.06) | 92.38 (1.94) | 98.60 (1.67) | ND | ND | ND | ND | ND | ND |
| Cheung et al. (31) | 41 | 123 | 70.4 | 65.7 (3.77) | 68.3 | 45.5 | NA | B | SD | ND | ND | ND | ND | 89.21 | 90.37 (1.71) | 73.73 (1.35) * | 77.79 (1.31) | ND | ND | ND | ND |
| Pillai et al. (32) | 21 | 34 | 68.2 (6.7) | 65.1 (8.3) | 57 | 59 | Brain Atrophy Measured | B | SD | ND | ND | 9.9 (0.1) | 9.8 (0.1) | 89.9 (2.1) | 85.3 (1.6) | 78.6 (1.8) | 73.5 (1.4) | ND | ND | ND | ND |
| Giménez Castejón et al. (34) | 33 | 25 | 68.74 (8.00) | 68.68 (8.21) | 45.5 | 60 | NA | M | SD | 259.48 (22.39) * | 274.96 (17.61) | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| Ferrari et al. (36) | 29 | 49 | 70.45 (5.51) | 68.32 (6.96) | 51.7 | 53 | GCL-IPL measured by M+A segmentation (in-house designed software) | B | SD | ND | ND | ND | ND | 92.79 (10.31) * | 97.49 (8.52) | 55.61 (8.17) | 58.18 (7.94) | ND | ND | ND | ND |
| Uchida et al. (37) | 22 | 36 | 68.9 (6.8) | 65.1 (8.3) | 64 | 61 | M+A segmentation | M | SD | 202.9 (3.9) | 207.3 (4.2) | 9.8 (0.1) | 9.8 (0.1) | ND | ND | ND | ND | ND | ND | 174.3 (3.1) [124.2 (3.0) ONL-EZ + 48.7 (1.4) EZ-REP] | 180.2 (2.8) [131.0 (2.9) ONL-EZ + 49.2 (1.3) EZ-RPE] |
| Shao et al. (38) | 24 | 21 | 69 (8) | 68 (7) | 41.6 | 52.3 | NA | M | SD | VNR, but significant* | VNR | ND | ND | ND | ND | 76* | 79 | ND | ND | ND | ND |
| Lad et al. (39) | 15 | 18 | 73.07 | 75.17 | 5.3 | 4.4 | M+A segmentation | B | SD | ND | ND | ND | ND | 95.69 (10.92) | 97.15 (8.94) | 63.71 (7.12) | 64.08 (3.60) | ND | ND | ND | ND |
| Almeida et al. (40) | 23 | 24 | 67.43 | 64.58 | 82.6 | 66.6 | NA | B | SS | 268.9* (3.08) | 275.73 (2.26) | ND | ND | 103.50 (2.42) | 103.77 (2.00) | 62.78 (0.95) | 64.67 (0.83) | ND | ND | ND | ND |
Retinal scan location: macula (M), circumpapillary (CP), and both (B); OCT technique: spectral domain (SD), time domain (TD), and source sweep (SS).
RNFL, retinal nerve fiber layer; M+A segmentation, manual and automated segmentation; GCL-IPL, retinal ganglion cell layer; VNR, measured, but value not reported; ND, not done; HA, hippocampal atrophy.
Results of this study are reported as the change in layers, and no individual values are reported.
*
Statistically significant difference.