Table 3.
Quality assessment of the 15 studies meeting inclusion criteria.
| Study | Diagnostic criteria | Biomarkers (MCI) | Biomarkers (NC) | Collection of data | Cross-sectional/longitudinal data | Follow-up | Double-blind | Use of APOSTEL |
|---|---|---|---|---|---|---|---|---|
| Paquet et al. (21) | NINCDS-ADRDA (22) | No | No | Prospective | Cross-sectional | No | No | No |
| Kesler et al. (23) | Petersen Criteria (24) | No | No | Prospective | Cross-sectional | No | No | No |
| Shen et al. (25) | Petersen Criteria (24) | No | No | Prospective | Cross-sectional | No | No | No |
| Ascaso et al. (26) | Winbald (27) | No | No | Prospective | Cross-sectional | No | No | No |
| Oktem et al. (28) | Not mentioned | No | No | Prospective | Cross-sectional | No | No | No |
| Liu D et al. (29) | Petersen Criteria (24) | No | No | Prospective | Cross-sectional | No | No | No |
| Gao et al. (30) | Petersen Criteria (24) | No | No | Prospective | Cross-sectional | No | No | No |
| Cheung et al. (31) | Petersen Criteria (24) | No | No | Prospective | Cross-sectional | No | No | No |
| Pillai et al. (32) | NIA-AA (33) | Hippocampal atrophy | Non-hippocampal atrophy | Prospective | Cross-sectional | No | No | Yes |
| Giménez Castejón et al. (34) | Neurological examination and DSM-IV (35) | No | No | Retrospective | Cross-sectional | No | No | No |
| Ferrari et al. (36) | NIA-AA (33) | No | No | Prospective | Cross-sectional | No | No | Yes |
| Uchida et al. (37) | NIA-AA (33) | No | No | Prospective | Cross-sectional | No | No | Yes |
| Shao et al. (38) | NIA-AA (33) | No | No | Prospective | Cross-sectional | No | No | Yes |
| Lad et al. (39) | NINCDS-ADRD (22) | No | No | Prospective | Cross-sectional | No | No | Yes |
| Almeida et al. (40) | NINCDS-ADRDA (22) | No | No | Prospective | Cross-sectional | No | No | Yes |
MCI, mild cognitive impairment; NC, normal controls; MRI, magnetic resonance imaging; NINCDS-ADRD, National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer Disease and Related Disorders Association; NIA-AA, National Institutes of Health-Alzheimer's Association.
Results of this study are reported as the change in layers, and no individual values were reported.