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. 2020 Oct 16;7:588913. doi: 10.3389/fmolb.2020.588913

FIGURE 3.

FIGURE 3

(A) A crystal structure of A. fumigatus calcineurin A and B, FKBP12, and FK506 [protein data bank (PDB): 6TZ7]. Calcineurin is a protein phosphatase comprising of a catalytic (green) and a regulatory subunit (yellow). The complex of FK506 (red) and FKBP12 (cyan) interacts with the calcineurin heterodimer to form a ternary complex and inhibit calcineurin function. (B) In the ribbon diagrams of human (left) and A. fumigatus (right) FKBP12-FK506, β sheets wrap around the α helix and the extended loops (such as the 80 and 40s loops) surround the FK506 binding pocket. Left: FK506-HsFKBP12 (PDB: 1FKJ), right: FK506-AfFKBP12 (PDB: 6TZ7). (C) Alignment of amino acids of the 40 and 80s loops of FKBP12. Hs, human; Af, A. fumigatus; Cn, C. neoformans; Ca, C. albicans; Mc, M. circinelloides. *Residue numbers are in respect to AfFKBP12.