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. 2020 Oct 26;12(10):501–512. doi: 10.4330/wjc.v12.i10.501

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Forest plot for the primary composite endpoint overall side-effects showing an individual and pooled risk ratio for randomized controlled trials comparing soluble guanylate cyclase stimulators to control. A: Pooled composite endpoint; B: Overall side-effects. The pooled risk ratio (RR) with 95% confidence interval (CI) were calculated using random-effects models. Weight refers to the contribution of each study to the overall pooled estimate of treatment effect. Each square and horizontal line denotes the point estimate and 95%CI for each trial’s RR, respectively. The diamonds signify the pooled RR; the diamond’s centre denotes the point estimate and width denotes the 95%CI. CI: Confidence interval; sGC: Soluble guanylate cyclase.