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. 2020 Oct 26;12(10):1184–1195. doi: 10.4252/wjsc.v12.i10.1184

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Liver organoids maintain the function of hepatocytes and prolong their survival time. A: Hematoxylin and eosin (HE) staining, periodic acid-Schiff (PAS) staining, immunofluorescence staining for albumin (ALB; green), and immunohistochemical staining for Ki67. The nuclei were counterstained with DAPI (blue). Scale bars = 100 μm; B: Gene expression analysis by q-PCR. Data were normalized to hepatocytes (H group); C: Secretion of albumin was measured by ELISA on days 2, 4, 6, 8, 14, and 20; D: Urea synthesis was measured on days 2, 4, 6, 8, 14, and 20. ^aP < 0.05 vs the organoid (H+M+E group). H+M+E group: Hepatocytes and MSCs seeded on ECM-gel pre-coated plate; H+E: Hepatocytes seeded on ECM-gel pre-coated plate; H+M: Hepatocytes and MSCs seeded on ECM-gel free plate; H group: Hepatocytes seeded on ECM-gel free plate; ECM: Extracellular matrix.