Table 2.
Correlations between HSP90s gene expression and biomarker expression of subsets of TIICs in BRAC from the TIMER.
| Types of TIICs | Gene markers | HSP90AA1 | HSP90AB1 | HSP90B1 | TRAP1 | ||||
|---|---|---|---|---|---|---|---|---|---|
| R | P | R | P | R | P | R | P | ||
| B cell | CD19 | -0.02 | 4.90E-01 | -0.01 | 7.71E-01 | 0.01 | 8.13E-01 | 0.04 | 2.19E-01 |
| CD79A | -0.04 | 1.81E-01 | 0.00 | 9.59E-01 | 0.00 | 9.37E-01 | 0.02 | 5.76E-01 | |
|
| |||||||||
| T cell (general) | CD3D | -0.08 | 1.53 E -02 | -0.03 | 3.43E-01 | 0.02 | 4.88E-01 | -0.01 | 6.66E-01 |
| CD2 | 0.02 | 5.01E-01 | 0.04 | 1.90E-01 | 0.08 | 1.62 E -02 | -0.02 | 5.87E-01 | |
|
| |||||||||
| Th1 | TBX21 | -0.05 | 1.42E-01 | 0.02 | 5.04E-01 | 0.06 | 4.77 E -02 | 0.02 | 6.08E-01 |
| STAT4 | 0.06 | 7.49E-02 | 0.01 | 7.21E-01 | 0.08 | 7.90 E -03 | -0.10 | 2.04 E -03 | |
| STAT1 | 0.33 | 1.08 E -26 | 0.29 | 1.25 E -20 | 0.34 | 3.99 E -28 | 0.03 | 3.26E-01 | |
| TNF | 0.03 | 3.79E-01 | 0.08 | 9.84 E -03 | 0.13 | 4.54 E -05 | 0.16 | 6.65 E -07 | |
| IFNG | 0.08 | 1.17 E -02 | 0.12 | 2.14 E -04 | 0.20 | 2.28 E -10 | 0.01 | 7.89E-01 | |
|
| |||||||||
| Th2 | GATA3 | 0.02 | 5.29E-01 | -0.04 | 2.66E-01 | -0.20 | 3.90 E -10 | 0.02 | 6.23E-01 |
| STAT6 | 0.01 | 7.19E-01 | -0.05 | 1.31E-01 | -0.12 | 2.52 E -04 | 0.07 | 2.13 E -02 | |
| IL13 | -0.02 | 5.17E-01 | 0.02 | 5.00E-01 | 0.03 | 2.99E-01 | -0.02 | 5.44E-01 | |
| STAT5A | -0.16 | 2.45 E -07 | -0.12 | 2.16 E -04 | -0.08 | 9.34 E -03 | 0.10 | 1.66 E -03 | |
|
| |||||||||
| Tfh | BCL6 | 0.00 | 8.88E-01 | -0.11 | 7.79 E -04 | -0.03 | 3.59E-01 | -0.06 | 4.91 E -02 |
| IL21 | 0.14 | 9.53 E -06 | 0.15 | 2.34 E -06 | 0.16 | 4.56 E -07 | -0.01 | 7.24E-01 | |
|
| |||||||||
| Th17 | STAT3 | 0.22 | 1.13 E -12 | 0.09 | 3.25 E -03 | 0.17 | 1.03 E -07 | 0.07 | 1.82 E -02 |
| IL17A | 0.05 | 1.19E-01 | 0.09 | 4.78 E -03 | 0.12 | 1.04 E -04 | 0.01 | 7.77E-01 | |
|
| |||||||||
| Treg | FOXP3 | 0.14 | 6.97 E -06 | 0.15 | 1.76 E -06 | 0.13 | 2.50 E -05 | 0.04 | 2.43E-01 |
| CCR8 | 0.32 | 4.12 E -25 | 0.28 | 3.19 E -19 | 0.23 | 1.86 E -13 | 0.05 | 1.10E-01 | |
| TGFB1 | -0.13 | 4.31 E -05 | -0.16 | 7.90 E -07 | -0.12 | 9.55 E -05 | -0.06 | 6.26E-02 | |
|
| |||||||||
| CD8+ T | CD8A | 0.00 | 9.85E-01 | 0.04 | 2.59E-01 | 0.05 | 1.25E-01 | -0.02 | 6.23E-01 |
| CD8B | -0.03 | 3.52E-01 | 0.00 | 9.95E-01 | 0.04 | 1.98E-01 | 0.02 | 4.75E-01 | |
|
| |||||||||
| T cell exhaustion | PDCD1 | -0.08 | 1.04 E -02 | 0.00 | 9.63E-01 | 0.02 | 4.87E-01 | 0.03 | 3.32E-01 |
| CTLA4 | 0.07 | 2.95 E -02 | 0.11 | 8.57 E -04 | 0.17 | 7.80 E -08 | 0.05 | 1.56E-01 | |
| LAG3 | 0.01 | 8.24E-01 | 0.10 | 2.02 E -03 | 0.12 | 8.62 E -05 | 0.05 | 9.93E-02 | |
| TIM3 | 0.15 | 1.35 E -06 | 0.08 | 8.06 E -03 | 0.21 | 2.01 E -11 | -0.05 | 9.84E-02 | |
| GZMB | 0.03 | 2.80E-01 | 0.09 | 2.87 E -03 | 0.17 | 8.65 E -08 | 0.02 | 4.44E-01 | |
|
| |||||||||
| NK cell | KIR2DL1 | 0.03 | 2.77E-01 | 0.08 | 1.20 E -02 | 0.13 | 1.96 E -05 | -0.01 | 7.62E-01 |
| KIR3DL3 | 0.00 | 9.47E-01 | 0.04 | 2.64E-01 | 0.11 | 3.48 E -04 | -0.02 | 5.83E-01 | |
| KIR3DL1 | 0.01 | 6.77E-01 | 0.04 | 2.14E-01 | 0.10 | 1.47 E -03 | -0.01 | 7.28E-01 | |
| KIR3DL2 | 0.02 | 4.77E-01 | 0.06 | 8.03E-02 | 0.07 | 2.20 E -02 | -0.01 | 7.71E-01 | |
| KIR3DL3 | 0.00 | 9.47E-01 | 0.04 | 2.64E-01 | 0.11 | 3.48 E -04 | -0.02 | 5.83E-01 | |
| KIR2DS4 | 0.03 | 3.87E-01 | 0.07 | 2.49 E -02 | 0.09 | 4.81 E -03 | -0.03 | 3.58E-01 | |
|
| |||||||||
| Neutrophils | CD11b | 0.04 | 2.60E-01 | -0.03 | 3.98E-01 | 0.07 | 3.23 E -02 | 0.06 | 5.79 E -02 |
| CCR7 | -0.01 | 6.45E-01 | 0.03 | 3.75E-01 | -0.03 | 3.37E-01 | -0.01 | 7.77E-01 | |
| CD66b | 0.00 | 9.75E-01 | -0.04 | 1.83E-01 | 0.00 | 8.80E-01 | -0.03 | 3.61E-01 | |
|
| |||||||||
| M1 macrophages | NOS2 | 0.03 | 3.39E-01 | 0.06 | 4.50 E -02 | 0.06 | 6.34E-02 | -0.07 | 2.10 E -02 |
| PTGS2 | 0.02 | 4.91E-01 | -0.01 | 7.49E-01 | 0.10 | 1.17 E -03 | -0.12 | 1.40 E -04 | |
| IRF5 | 0.01 | 7.84E-01 | 0.11 | 2.92 E -04 | 0.16 | 6.25 E -07 | 0.02 | 5.31E-01 | |
|
| |||||||||
| M2 macrophages | CD163 | 0.21 | 3.01 E -11 | 0.23 | 4.52 E -13 | 0.29 | 3.17 E -21 | 0.02 | 6.25E-01 |
| VSIG4 | 0.09 | 6.51 E -03 | 0.08 | 1.25 E -02 | 0.16 | 8.74 E -07 | -0.05 | 1.02E-01 | |
| MS4A4A | 0.16 | 2.37 E -07 | 0.13 | 5.38 E -05 | 0.19 | 7.28 E -10 | -0.09 | 5.86 E -03 | |
|
| |||||||||
| TAM | CCL2 | 0.06 | 5.66E-02 | 0.04 | 1.70E-01 | 0.14 | 5.57 E -06 | -0.08 | 1.20 E -02 |
| CD68 | 0.16 | 3.26 E -07 | 0.11 | 4.71 E -04 | 0.21 | 1.45 E -11 | -0.01 | 8.13E-01 | |
| IL10 | 0.19 | 1.42 E -09 | 0.15 | 2.04 E -06 | 0.22 | 1.38 E -12 | -0.01 | 6.68E-01 | |
|
| |||||||||
| Monocyte | CD86 | 0.14 | 6.49 E -06 | 0.11 | 5.58 E -04 | 0.25 | 3.58 E -15 | -0.05 | 1.28E-01 |
| CD115 | -0.04 | 2.63E-01 | -0.03 | 2.88E-01 | 0.11 | 2.88 E -04 | -0.07 | 2.22 E -02 | |
|
| |||||||||
| DC | HLA-DPB1 | -0.19 | 1.34 E -09 | -0.17 | 8.39 E -08 | -0.08 | 7.37 E -03 | -0.03 | 3.46E-01 |
| HLA-DRA | 0.04 | 2.25E-01 | -0.02 | 6.17E-01 | 0.10 | 1.45 E -03 | -0.05 | 1.09E-01 | |
| HLA-DQB1 | -0.11 | 7.12 E -04 | -0.07 | 1.90 E -02 | -0.01 | 8.42E-01 | 0.04 | 2.44E-01 | |
| HLA-DPA1 | 0.00 | 8.91E-01 | -0.06 | 5.51E-02 | 0.08 | 1.70 E -02 | -0.08 | 1.53 E -02 | |
| CD1C | -0.14 | 1.05 E -05 | -0.15 | 3.10 E -06 | -0.15 | 1.49 E -06 | -0.08 | 7.67 E -03 | |
| NRP1 | 0.16 | 5.78 E -07 | 0.00 | 8.97E-01 | 0.09 | 5.97 E -03 | -0.22 | 4.26 E -12 | |
| CD11c | 0.03 | 3.55E-01 | 0.02 | 6.27E-01 | 0.07 | 3.68 E -02 | 0.00 | 9.28E-01 | |
Note: the correlation analysis was adjusted for the tumor purity. P values with statistical significance are shown in bold. Abbreviations: TAM: tumor-associated macrophage; Th: helper T cell; Tfh: follicular helper T cell; Treg: regulatory T cell; NK: natural killer cell; R: R value of Spearman's correlation.