Table 3.
Correlations between HSP90s gene expression and biomarker expression of subsets of TIICs in BRAC from the GEPIA.
| Types of TIICs | Biomarker | HSP90AA1 | HSP90AB1 | HSP90B1 | TRAP1 | ||||
|---|---|---|---|---|---|---|---|---|---|
| R | P | R | P | R | P | R | P | ||
| B cell | CD19 | -0.17 | 2.20 E -08 | -0.19 | 5.20 E -10 | -0.08 | 5.50 E -03 | -0.11 | 4.40 E -04 |
| CD79A | -0.18 | 9.00 E -10 | -0.18 | 5.30 E -09 | -0.11 | 2.60 E -04 | -0.15 | 1.30 E -06 | |
|
| |||||||||
| T cell (general) | CD3D | -0.22 | 9.70 E -14 | -0.23 | 3.00 E -14 | -0.08 | 5.90 E -03 | -0.17 | 7.60 E -09 |
| CD3E | -0.18 | 1.90 E -09 | -0.19 | 3.50 E -10 | -0.07 | 1.70 E -02 | -0.19 | 2.70 E -10 | |
| CD2 | -0.12 | 1.40 E -04 | -0.13 | 1.20 E -05 | -0.03 | 3.60E-01 | -0.17 | 2.00 E -08 | |
|
| |||||||||
| Th1 | TBX21 | -0.17 | 2.80 E -08 | -0.15 | 3.50 E -07 | -0.04 | 1.90E-01 | -0.15 | 6.40 E -07 |
| STAT4 | -0.09 | 4.50 E -03 | -0.14 | 3.80 E -06 | -0.03 | 3.80E-01 | -0.22 | 1.30 E -13 | |
| STAT1 | 0.29 | 3.10 E -22 | 0.26 | 1.10 E -17 | 0.27 | 4.60 E -19 | -0.01 | 7.20E-01 | |
| TNF | -0.01 | 7.00E-01 | 0.05 | 1.20E-01 | 0.11 | 5.10 E -04 | 0.10 | 7.90 E -04 | |
| IFNG | -0.02 | 5.40E-01 | -0.02 | 4.80E-01 | 0.10 | 1.10 E -03 | -0.11 | 1.90 E -04 | |
|
| |||||||||
| Th2 | GATA3 | 0.13 | 1.50 E -05 | 0.13 | 1.20 E -05 | -0.11 | 3.30 E -04 | 0.13 | 1.20 E -05 |
| STAT6 | 0.10 | 8.70 E -04 | 0.07 | 2.30 E -02 | -0.06 | 4.20 E -02 | 0.10 | 1.60 E -03 | |
| IL13 | -0.03 | 3.10E-01 | -0.03 | 2.90E-01 | 0.00 | 9.40E-01 | -0.07 | 1.60 E -02 | |
| STAT5A | -0.16 | 1.80 E -07 | -0.10 | 8.40 E -04 | -0.10 | 6.70 E -04 | 0.05 | 9.20E-02 | |
|
| |||||||||
| Tfh | BCL6 | 0.03 | 3.60E-01 | -0.02 | 5.00E-01 | -0.04 | 2.50E-01 | -0.02 | 5.50E-01 |
| IL21 | 0.08 | 1.30 E -02 | 0.06 | 4.60 E -02 | 0.09 | 3.30 E -03 | -0.11 | 2.30 E -04 | |
|
| |||||||||
| Th17 | STAT3 | 0.25 | 1.60 E -17 | 0.20 | 7.80 E -11 | 0.14 | 6.40 E -06 | 0.13 | 3.00 E -05 |
| IL17A | 0.00 | 8.80E-01 | 0.02 | 5.10E-01 | 0.07 | 2.20 E -02 | -0.08 | 6.20 E -03 | |
|
| |||||||||
| Treg | FOXP3 | -0.01 | 7.60E-01 | -0.02 | 4.20E-01 | 0.02 | 5.10E-01 | -0.10 | 1.00 E -03 |
| CCR8 | 0.22 | 1.00 E -13 | 0.19 | 3.00 E -10 | 0.14 | 8.10 E -06 | -0.05 | 1.30E-01 | |
| TGFB1 | -0.22 | 5.50 E -13 | -0.24 | 3.10 E -16 | -0.18 | 2.50 E -09 | -0.14 | 7.00 E -06 | |
|
| |||||||||
| CD8+ T | CD8A | -0.13 | 1.60 E -05 | -0.13 | 8.40 E -06 | -0.05 | 1.10E-01 | -0.17 | 9.70 E -09 |
| CD8B | -0.16 | 2.50 E -07 | -0.17 | 2.20 E -08 | -0.06 | 6.80E-02 | -0.13 | 1.40 E -05 | |
|
| |||||||||
| T cell exhaustion | PDCD1 | -0.17 | 9.30 E -09 | -0.15 | 1.20 E -06 | -0.06 | 5.30E-02 | -0.11 | 1.70 E -04 |
| CTLA4 | -0.05 | 1.40E-01 | -0.05 | 8.20E-02 | 0.07 | 2.70 E -02 | -0.10 | 1.10 E -03 | |
| LAG3 | -0.10 | 1.60 E -03 | -0.05 | 9.10E-02 | 0.05 | 9.00E-02 | -0.03 | 3.00E-01 | |
| TIM3 | 0.09 | 3.70 E -03 | 0.03 | 3.30E-01 | 0.13 | 1.30 E -05 | -0.12 | 1.30 E -04 | |
| GZMB | -0.10 | 5.70 E -04 | -0.09 | 3.00 E -03 | 0.06 | 4.20 E -02 | -0.11 | 1.90 E -04 | |
|
| |||||||||
| NK cell | KIR2DL1 | -0.02 | 5.40E-01 | 0.00 | 8.90E-01 | 0.10 | 6.90 E -04 | -0.11 | 4.70 E -04 |
| KIR3DL3 | 0.00 | 9.10E-01 | 0.04 | 2.50E-01 | 0.10 | 6.50 E -04 | -0.02 | 4.60E-01 | |
| KIR3DL1 | -0.08 | 1.20 E -02 | -0.07 | 2.10 E -02 | 0.04 | 1.70E-01 | -0.12 | 4.80 E -05 | |
| KIR3DL2 | -0.06 | 3.70 E -02 | -0.04 | 2.20E-01 | 0.03 | 3.60E-01 | -0.11 | 2.20 E -04 | |
| KIR3DL3 | 0.00 | 9.10E-01 | 0.04 | 2.50E-01 | 0.10 | 6.50 E -04 | -0.02 | 4.60E-01 | |
| KIR2DS4 | -0.03 | 3.00E-01 | -0.03 | 3.50E-01 | 0.03 | 3.30E-01 | -0.14 | 4.90 E -06 | |
|
| |||||||||
| Neutrophils | CD11b | 0.00 | 9.40E-01 | -0.06 | 4.90 E -02 | -0.01 | 7.20E-01 | 0.01 | 6.90E-01 |
| CCR7 | -0.13 | 9.80 E -06 | -0.12 | 1.20 E -04 | -0.11 | 2.70 E -04 | -0.14 | 2.10 E -06 | |
| CD66b | 0.00 | 1.00E+00 | -0.03 | 4.10E-01 | 0.03 | 3.10E-01 | -0.03 | 2.60E-01 | |
|
| |||||||||
| M1 macrophages | NOS2 | 0.08 | 1.10 E -02 | 0.11 | 4.20 E -04 | 0.05 | 1.40E-01 | -0.06 | 5.40E-02 |
| PTGS2 | -0.04 | 1.90E-01 | -0.06 | 3.60 E -02 | 0.04 | 2.10E-01 | -0.17 | 7.60 E -09 | |
| IRF5 | 0.00 | 9.50E-01 | 0.08 | 8.20 E -03 | 0.14 | 6.00 E -06 | 0.00 | 8.70E-01 | |
|
| |||||||||
| M2 macrophages | CD163 | 0.02 | 4.20E-01 | 0.04 | 1.90E-01 | 0.15 | 8.40 E -07 | -0.09 | 2.20 E -03 |
| VSIG4 | 0.01 | 7.10E-01 | 0.00 | 8.90E-01 | 0.08 | 1.10 E -02 | -0.10 | 5.50 E -04 | |
| MS4A4A | 0.06 | 6.70E-02 | 0.02 | 4.90E-01 | 0.10 | 1.80 E -03 | -0.15 | 3.50 E -07 | |
|
| |||||||||
| TAM | CCL2 | -0.05 | 1.20E-01 | -0.07 | 3.40 E -02 | 0.08 | 1.20 E -02 | -0.15 | 4.50 E -07 |
| CD68 | 0.15 | 3.40 E -07 | 0.10 | 1.50 E -03 | 0.08 | 1.20 E -02 | -0.07 | 1.90 E -02 | |
| IL10 | 0.14 | 3.00 E -06 | 0.11 | 1.90 E -04 | 0.14 | 7.80 E -06 | -0.09 | 4.10 E -03 | |
|
| |||||||||
| Monocyte | CD86 | 0.07 | 3.20 E -02 | 0.03 | 3.50E-01 | 0.15 | 3.60 E -07 | -0.14 | 2.00 E -06 |
| CD115 | -0.09 | 3.00 E -03 | -0.08 | 8.40 E -03 | 0.03 | 3.50E-01 | -0.13 | 2.30 E -05 | |
|
| |||||||||
| DC | HLA-DPB1 | -0.25 | 2.20 E -16 | -0.26 | 7.70 E -18 | -0.14 | 1.80 E -06 | -0.16 | 5.70 E -08 |
| HLA-DRA | -0.08 | 9.60 E -03 | -0.13 | 8.70 E -06 | -0.01 | 7.20E-01 | -0.16 | 6.80 E -08 | |
| HLA-DQB1 | -0.20 | 6.80 E -11 | -0.20 | 1.40 E -11 | -0.06 | 5.00 E -02 | -0.09 | 4.30 E -03 | |
| HLA-DPA1 | -0.09 | 5.20 E -03 | -0.14 | 2.80 E -06 | -0.02 | 6.10E-01 | -0.16 | 4.60 E -08 | |
| CD1C | -0.24 | 6.90 E -16 | -0.24 | 2.80 E -16 | -0.20 | 1.90 E -11 | -0.18 | 3.20 E -09 | |
| NRP1 | 0.12 | 8.30 E -05 | 0.01 | 8.00E-01 | 0.02 | 5.10E-01 | -0.20 | 1.70 E -11 | |
| CD11c | -0.07 | 2.80 E -02 | -0.09 | 4.20 E -03 | -0.03 | 3.20E-01 | -0.08 | 5.90 E -03 | |
Note: the same as Table 2.