Table 2.
Gene ontology analysis of 18 central hub genes in UC.
| Category | Term | Count | P value | Genes | --log10 (P value) |
|---|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0070098~chemokine-mediated signaling pathway | 7 | 8.79E-12 | CCL20, CXCL2, CXCR1, CXCL8, CXCL11, CXCL10 | 7.977397 |
| GOTERM_BP_DIRECT | GO:0006954~inflammatory response | 8 | 3.40E-09 | CCL20, PTGS2, CXCL2, CXCL8, NOS2, CXCL11, CXCL10 | 5.389683 |
| GOTERM_BP_DIRECT | GO:0042127~regulation of cell proliferation | 7 | 1.41E-08 | PTGS2, CXCL2, CXCL8, NOS2, CXCL11, CXCL10 | 4.772917 |
| GOTERM_BP_DIRECT | GO:0006955~immune response | 7 | 1.42E-07 | CXCL2, IL1B, CXCL8, CXCL11, IL1A, CXCL10 | 3.770405 |
| GOTERM_BP_DIRECT | GO:0006935~chemotaxis | 5 | 3.20E-07 | CCL20, CXCR1, CXCL11, CXCL10 | 3.415649 |
| GOTERM_BP_DIRECT | GO:0032496~response to lipopolysaccharide | 5 | 2.71E-06 | CXCL2, CXCL8, CXCL11, CXCL10 | 2.488617 |
| GOTERM_BP_DIRECT | GO:0060326~cell chemotaxis | 4 | 2.42E-05 | CCL20, CXCL2, CXCL10, ICAM1, | 1.537263 |
| GOTERM_CC_DIRECT | GO:0005615~extracellular space | 13 | 1.26E-11 | CCL20, MMP9, IL1RN, CXCL2, IL1B, CXCL8,CXCL11,SELE,IL1A, CXCL10, TIMP1 | 7.981942 |
| GOTERM_MF_DIRECT | GO:0008009~chemokine activity | 6 | 7.11E-10 | CCL20, CXCL2, CXCL8, CXCL11, CXCL10 | 6.189676 |
| GOTERM_MF_DIRECT | GO:0045236~CXCR chemokine receptor binding | 4 | 2.98E-07 | CXCL2, CXCL8, CXCL10 | 3.567109 |