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. 2020 Oct 29;5:250. doi: 10.1038/s41392-020-00348-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Adenosine-axis in the tumor microenvironment mediates immune suppression of NK cells. In the tumor microenvironment, stress such as hypoxia increases extracellular ATP levels and CD73 expression on cancer cells, leading to adenosine (ADO) upregulation and the activation of downstream signaling through A_2AR on NK cells. ADO/A_2AR signaling results in dysfunction of NK cell metabolic and effector functions