FIGURE 4.

Structures of the N-terminal domain of Spike protein after 200 ns of simulation showing the relative orientation of solvent exposed loops. (A) The solvent exposed loops of NTD; the N-terminal β strand, β8–β9, β9–β10, and β14–β15 are shown in red, blue, green and yellow colors, respectively. Time-averaged conformation of N- terminal domain of SARS-CoV-2 Spike protein at, (B) 10°C, (C) 20°C, (D) 30°C, (E) 40°C, and (F) 50°C showing the relative orientation of the polar and hydrophobic residues. The residues are shown in licorice. Polar resides are colored in light blue and hydrophobic in brown colors, respectively.