Table 3. Association Of Obesity-Related Measures With Atherosclerotic Cardiovascular Disease Events.
| Measure | All cohorts | Derivation cohort studiesa | Nonderivation cohort studiesb | |||
|---|---|---|---|---|---|---|
| C statistic (95% CI)c | P value | C statistic (95% CI) | P value | C statistic (95% CI) | P value | |
| BMI | 1.00 (0.96-1.04)c | NA | 1.02 (0.95-1.09)c | NA | 0.98 (0.94-1.03)c | NA |
| Waist circumference | 1.07 (1.03-1.11)c | NA | 1.06 (0.99-1.13)c | NA | 1.08 (1.03-1.13)c | NA |
| hsCRP | 1.07 (1.05-1.09)c | NA | (1.08-1.19)c | NA | 1.06 (1.03-1.09)c | NA |
| Model discrimination | ||||||
| Overall (standard PCE model) | 0.760 (0.753-0.767) | 0.758 (0.746-0.770) | 0.761 (0.752-0.770) | |||
| Overall + BMI | 0.763 (0.756-0.770) | .06 | 0.760 (0.748-0.772) | .36 | 0.766 (0.757-0.774) | .23 |
| Overall + waist circumference | 0.763 (0.756-0.770) | .88 | 0.760 (0.748-0.772) | .03 | 0.766 (0.757-0.774) | .48 |
| Overall + hsCRP | 0.762 (0.755-0.769) | .07 | 0.757 (0.745-0.769) | .99 | 0.764 (0.756-0.773) | .07 |
| Overall + BMI + waist circumference + hsCRP | 0.764 (0.757-0.771) | <.001 | 0.760 (0.747-0.771) | .003 | 0.767 (0.759-0.776) | .001 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); hsCRP, high sensitivity C-reactive protein; NA, not applicable; PCE, pooled cohort equations.
a
Atherosclerosis Risk in Communities, Coronary Artery Risk Development in Young Adults, and Cardiovascular Health Study.
b
Dallas Heart Study, Framingham Heart Study Third Generation, Jackson Heart Study, Multi-Ethnic Study of Atherosclerosis, and Reasons for Geographic and Racial Differences in Stroke.
c
Hazard ratios per 1-SD change in the exposure, with the addition of each obesity-related measure to a standard pooled cohort equation–based risk-estimation model.