AA indicates anaplastic astrocytoma; C1D1, cycle 1 day 1; GBM, glioblastoma multiforme; HR, hazard ratio; IDH1, isocitrate dehydrogenase 1; KPS, Karnofsky performance status; MGMT, O6-methylgaunine-DNA-methyltransferase; SOC, standard of care; and Toca, vocimagene amiretrorepvec (Toca 511) followed by flucytosine (Toca FC).