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. 2020 Oct 16;11:566303. doi: 10.3389/fphys.2020.566303

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Copyright © 2020 Epp, Schmid, Weber and Jenny.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network representation of a realistic microvascular network and visualization of the tracking of individual red blood cells. (A) Tortuous structure of a realistic microvascular network. (B) Corresponding network consisting of nodes and edges. The blood vessels are represented by straight pipes. (C) Individual red blood cells that follow the flow field and dynamically affect the flow resistance in the network. (D) Schematic of red blood cells squeezing through the vessels and bifurcation rule. (E) Example of a set of activated edges in which the average perfusion will be increased, i.e., where a target flow rate is prescribed, in response to diameter adaptations.