Figure 4.

The dependence of the stationary rate of total H₂O₂ production by CII on the succinate concentration upon inhibition of Complex III. Computer simulation (line) is compared to experimental data (black triangles) on SMP from rat heart mitochondria upon inhibition of Complex III by myxothiazol (1.6 ìM; Grivennikova et al., 2017). All computer simulations were made at model parameter values as for Figure 2 except AA5 = 0, k₂₉ = 0.005 s⁻¹, and the total concentration of CII, CIIt, equal to 97 μM.