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. 2020 Oct 16;14:568813. doi: 10.3389/fnins.2020.568813

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Copyright © 2020 Kang, Choi, Lee, Kho, Jeong, Hong, Kang, Park, Song, Choi, Lim and Suh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cerebrolysin decreases level of TNF-α after pilocarpine-induced seizure. The administration of cerebrolysin decreased TNF-α after pilocarpine induced seizure. (A) indicates the level of TNF-α in the hippocampus. After seizure, the administration of cerebrolysin decreased TNF-α expression in the hippocampus compared to vehicle groups. (B) A graph of the TNF-α. (C) TNF-α (red) and DAPI (blue) in the hippocampal CA1 and CA3 regions. The data are mean ± SEM, n = 3–4 from each seizure group. *p < 0.05 vs. vehicle-treated group; ^#p < 0.05 vs. sham-operated group (Kruskal–Wallis test with post hoc test: Chi square = 17.153, df = 3, p = 0.001).