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. 2020 Oct 16;14:568813. doi: 10.3389/fnins.2020.568813

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Copyright © 2020 Kang, Choi, Lee, Kho, Jeong, Hong, Kang, Park, Song, Choi, Lim and Suh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cerebrolysin decreases the number of apoptotic cells after pilocarpine-induced seizure. The administration of cerebrolysin decreases apoptosis after pilocarpine-induced seizure. (A,C) Cleaved caspase-3 (green) in the hippocampal CA1 and CA3 regions. After a seizure, the administration of cerebrolysin for 1 week decreased the number of apoptotic cells in the hippocampal CA1 and CA3 regions compared to the seizure-vehicle groups. Scale bar = 20 μm. (B,D) A graph that shows the number of apoptotic cells. The data are the mean ± SEM, n = 5–7 for each seizure group. *p < 0.05 [Mann–Whitney U-test: (B) z = 2.842, p = 0.03, (D) z = 2.517, p = 0.01].