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. 2020 Oct 16;14:572328. doi: 10.3389/fnins.2020.572328

FIGURE 1.

FIGURE 1

D-Norpseudoephedrine (NPE) leads to weight loss, suppresses food intake, and NPE increases locomotor activity. (A) Left panel: Change in body weight (g) relative to baseline day (BL) over 7 consecutive injections of saline (Sal) or NPE at 10-, 20-, 40-, and 80-mg/kg doses (NPE10, NPE20, NPE40, and NPE80, respectively). The horizontal dotted line represents no change in body weight relative to BL. Right panel: Average body weight loss over 7 consecutive days of treatment. (B) Left panel: Change in chow intake (g) over 7 days. Right panel: Average change in chow intake. (C) Left panel: Locomotor activity induced by different doses of NPE. Right panel: Mean distance traveled follows inverted-U shape response. Bars represent the mean ± SEM. *p < 0.05 significantly different from saline-treated rats.