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. 2020 Oct 16;10:575711. doi: 10.3389/fonc.2020.575711

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Copyright © 2020 Wang, Guo, Zhang, Li, Xu, Li, Wang and Zhan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DNA damage repair (DDR) pathway genes had significant copy number variations (CNVs) in esophageal squamous cell cancer (ESCC). (A) A complex heatmap that shows the gene CNV profile in DDR pathways (samples with no CNVs are removed). The top panel presents the number of gene CNVs in each of ESCC samples, and the right panel shows the number of gene CNVs in each gene. (B) Amplification of homologous recombination (HR), non-homologous end joining (NHEJ), and the “DSB repair pathway” was associated with poorer overall survival. The amplification of MRE11-RAD50-NBS1 (MRN) complex genes (C), RAD54B, and RAD51B (D) was related to shorter overall survival.