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. 2020 Oct 16;10:575711. doi: 10.3389/fonc.2020.575711

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Copyright © 2020 Wang, Guo, Zhang, Li, Xu, Li, Wang and Zhan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The messenger RNA (mRNA) expression level of double-strand break (DSB) repair pathway genes was up-regulated in esophageal squamous cell cancer (ESCC). (A) A heatmap that depicts the mRNA expression profile of DSB repair pathway genes in ESCC and normal tissues from GSE53624 dataset. (B) Student’s t-test analysis showed that RAD54B, RAD51B, MRE11, NBS1, and PRKDC were up-regulated in ESCC with statistically significant P values. ESCC patients were divided into two groups based on the median expression values of DSB repair pathway genes, and survival analysis was then performed. High expression of RAD51B, MUS81, TOP3A, GEN1, and TP53BP1 was associated with poorer overall survival of ESCC patients (C).