Table 1.
Distribution of the 4 Pharmaceutically Targetable Receptors Within the GBM Microenvironment
| Tumor Compartment | IL-13RA2 | EphA2 | EphA3 | EphB2 |
|---|---|---|---|---|
| Differentiated tumor cells | + | + | + | + |
| Infiltrating tumor cells | + | + | + | + |
| Glioma-stem like cells | + | + | + | + |
| Neovascular | − | + | − | − |
| Tumor-infiltrating cells | − | + | + | − |
| Linked to survival | + | + | + | + |
| Normal brain | − | − | − | − |