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. Author manuscript; available in PMC: 2020 Oct 30.
Published in final edited form as: Nat Neurosci. 2019 Jun 17;22(7):1066–1074. doi: 10.1038/s41593-019-0416-1

Figure 4. Association of PRS with CUD.

Figure 4.

PRSs was generated for phenotypes related to cognition, personality, psychiatric disorders, reproduction and smoking behavior based on summary statistics from 22 published GWASs. The variance explained by the scores (Nagelkerke-R2) is given on the x-axis and the P-value from logistic regression for association of the PRS with CUD on the y-axis (based on analyses of 2,387 individuals with CUD and 48,985 controls). The vertical blue line indicate statistical significance (P=0.0023; correcting for 22 test). In PRS analyses of psychiatric disorders, individuals having a diagnosis of the respective psychiatric disorder being analysed (ADHD, schizophrenia, depressive symptoms and major depressive disorder) were excluded in the CUD target sample.