Table 1. Genome-wide significant SNPs associated with CUD.

Results for variants passing the threshold for genome-wide significance (P=5x10⁻⁸) in the associated locus at chromosome 8 in the primary GWAS (2,387 individuals with CUD and 48,985 controls) and/or in the meta-analysis with results from an independent cohort collected by deCODE (5,501 cases with CUD and 301,041 controls). Results for the index SNP (Index SNP) is shown together with results from supporting correlated SNPs in the locus (0.2 < r² < 0.7) (LD SNPs). Alleles for the variants (A1 and A2), frequency of A1 in controls (Frq A1 con), the odds ratio (OR) for the effect of A1, and P-values (P) are given. Two-sided P-values from logistic regression of the iPSYCH and deCODE cohorts and from inverse variance weighted fixed effects meta-analysis. Bolding of P values indicates genome-wide significance

				iPSYCH					deCODE					meta-analysis
Index SNP	LD SNPs	CHR	BP (hg19)	A1	A2	Frq A1 con	OR	P	A1	A2	Frq A1 con	OR	P	A1	A2	OR	P
rs56372821		8	27436500	A	G	0.163	0.728	9.31x10−12	A	G	0.144	0.878	3.27 x10−03	A	G	0.803	9.09 x10−12
	rs4732724	8	27423062	C	G	0.324	0.820	1.34 x10−08	C	G	0.367	0.905	1.60 x10−03	C	G	0.866	7.74 x10−10
	rs6558008	8	27438306	A	C	0.755	1.237	2.54 x10−08	C	A	0.228	0.915	1.45 x10−02	A	C	1.159	1.97 x10−08
	rs73229090	8	27442127	A	C	0.110	0.702	7.41 x10−10	A	C	0.105	0.881	1.30 x10−02	A	C	0.797	2.82 x10−09
	rs937220	8	27429730	A	G	0.259	0.8258	2.46 x10−07	A	G	0.269	0.912	7.56 x10−03	A	G	0.871	4.53 x10−08
	rs17466060	8	27422740	A	G	0.418	0.8594	3.94 x10−06	A	G	0.430	0.900	5.11 x10−04	A	G	0.881	1.29 x10−08