Table 1. FISH and IHC results.
| BL | HBL-DH/TH | HBS NOS | DLBCL | Total | ||
|---|---|---|---|---|---|---|
| Case number | 5 | 9 | 8 | 18 | 40 | |
| Hans algorithm | GCB/non-GCB | 5/0 | 9/0 | 7/1 | 7/11 | 28/12 |
| FISH | ||||||
| Rearrangement | ||||||
| MYC | 5 (100%) | 9 (100%) | 6 (75%) | 2 (11%) | 21 (53%) | |
| BCL2 | 0 (0%) | 8 (89%) | 0 (0%) | 3 (17%) | 11 (28%) | |
| BCL6 | 0 (0%) | 2 (22%) | 1 (13%) | 7 (39%) | 10 (25%) | |
| IHC | ||||||
| MYC | M1 (40-59%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (10%) | 2 (5%) |
| M2 (60-79%) | 0 (0%) | 3 (33%) | 2 (25%) | 5 (28%) | 10 (25%) | |
| M3 (80-100%) | 5 (100%) | 6 (67%) | 6 (75%) | 11 (61%) | 28 (70%) | |
| BCL2 | 0 (0%) | 9 (100%) | 5 (65%) | 17 (94%) | 31 (78%) | |
| BCL6 | 5 (100%) | 8 (89%) | 7 (88%) | 17 (94%) | 37 (93%) | |
| CD10 | 5 (100%) | 8 (89%) | 6 (75%) | 7 (39%) | 26 (65%) | |
| IRF4 | 5 (100%) | 2 (22%) | 4 (50%) | 16 (89%) | 27 (68%) | |
| Ki-67 | K1 (80-94%) | 0 (0%) | 2 (22%) | 0 (100%) | 8 (44%) | 10 (25%) |
| K2 (95-100%) | 5 (100%) | 7 (78%) | 8 (100%) | 10 (56%) | 30 (75%) | |
| DE lymphoma | Positive | 0 (0%) | 9 (100%) | 5 (63%) | 17 (94%) | 31 (78%) |
FISH: Fluorescence in situ hybridization, IHC: Immunohistochemistry, BL: Burkitt lymphoma, HBL-DH/TH: high-grade B-cell lymphoma double hit/triple hit, HBL NOS: high-grade B-cell lymphoma not otherwise specified, DLBCL: diffuse large B-cell lymphoma, GCB: germinal center B-cell lymphoma immunophenotype, DE lymphoma: double expressor lymphoma