. 2020 Oct 29;25(43):1900402. doi: 10.2807/1560-7917.ES.2020.25.43.1900402

Table 4. Total costs, treatments used and treatment outcomes for standard care and antimicrobial resistance point-of-care test strategies: all groups (n = 38,870).

Strategy	Total cost^a	Number of antibiotics used to treat NG			Number of optimal treatments^b	Number of suboptimal treatments^c	Number of MEITR^d	Number of treatment failures^e
Strategy	Total cost^a	Ceftriaxone	Azithromycin	Ciprofloxacin	Number of optimal treatments^b	Number of suboptimal treatments^c	Number of MEITR^d	Number of treatment failures^e
Standard care	GBP 2,856,168 (EUR 3,819,524)	38,870	38,870	0	37,162	1,708	NA	NA
A: Single POCT for ciprofloxacin; dual therapy	GBP 3,954,554 (EUR 5,288,385)	38,870	12,408	26,462	38,057	813	265	NA
B: Dual POCT for azithromycin and ciprofloxacin; dual therapy	GBP 4,093,844 (EUR 5,474,656)	38,870	36,825	1,373	38,822	48	267	NA
C: Dual POCT for ciprofloxacin and azithromycin; dual therapy	GBP 4,066,498 (EUR 5,438,086)	38,870	11,736	26,462	38,611	259	912	NA
D: Single POCT for azithromycin; monotherapy	GBP 3,271,684 (EUR 4,375,189)	2,080	36,825	2,045	38,164	706	372	34
E: Single POCT for ciprofloxacin; monotherapy	GBP 3,457,581 (EUR 4,623,788)	12,656	12,408	26,462	38,057	813	265	248

AMR: antimicrobial resistance; MEITR: missed earlier intended treatment regimen; NG: Neisseria gonorrhoeae; POCT: point-of-care test.

^a GBP costs were converted to EUR using a historic currency conversion of an average of 366 days from 1 July 2015 to 30 June 2016 [48]. For this time period, GBP 1 = EUR 1.34 , and EUR 1 = GBP 0.75.

^b ‘Optimal’ refers to a treatment regimen which cures the NG infection and does not contain any antibiotic against which there is resistance.

^c ‘Suboptimal’ refers to a treatment regimen which contains antibiotics against which there is NG resistance - if the treatment is a monotherapy it will result in treatment failure.

^d ‘Missed earlier intended treatment regimen’ (MEITR) refers to a treatment regimen which cures the NG infection and does not contain any antibiotic against which there is resistance, but a treatment regimen was used when an earlier intended treatment regimen would have provided optimal treatment – a MEITR is due to a false-resistant AMR POCT result.

^e ‘Treatment failure’ refers to failure to cure an NG infection due to resistance to an antibiotic given as monotherapy and is due to a false-susceptible AMR POCT result.