Table 2.
Background differences between premenopausal and postmenopausal women with urolithiasis
| Premenopausal female (n = 30) | Postmenopausal female (n = 103) | p value | |
|---|---|---|---|
| Age (years) | 41.1 ± 7.7 | 70.0 ± 9.2 | < 0.001 |
| BMI (kg/m2) | 23.1 ± 4.6 | 23.4 ± 4.9 | 0.77 |
| Age of onset (years) | 33.2 ± 9.0 | 56.4 ± 16.2 | < 0.001 |
| Previous history of urolithiasis | 14 (46.7) | 38 (44.7) | 0.67 |
| Presence of symptoms at clinic visits | 15 (50.0) | 55 (58.5) | 0.53 |
| Family history of stone | 5 (16.7) | 5 (21.7) | 0.22 |
| DM | 2 (6.7) | 16 (16.7) | 0.24 |
| HLP | 3 (10.0) | 28 (29.2) | 0.05 |
| HTN | 4 (13.3) | 40 (41.2) | 0.01 |
| PHP | 2 (6.9) | 5 (5.3) | 0.67 |
| RTA | 0 (0.0) | 2 (2.1) | 1.00 |
| Fluid recommendation | 24 (80.0) | 74 (76.3) | 0.85 |
| Nutrition recommendation | 28 (93.3) | 89 (91.8) | 1.00 |
| Bisphosphonate use | 2 (6.7) | 14 (13.6) | 0.52 |
| NaKCit use | 10 (33.3) | 27 (28.4) | 0.65 |
| Thiazide use | 0 (0.0) | 1 (1.1) | 1.00 |
| VitD supplementation | 1 (3.3) | 3 (3.2) | 1.00 |
| BMD (g/cm2) | 0.93 ± 0.15 | 0.81 ± 0.18 | 0.001 |
| T-score | − 0.83 ± 1.47 | − 2.01 ± 1.72 | 0.001 |
| Serum Ca (mg/dL) | 9.1 ± 0.5 | 9.3 ± 0.4 | 0.05 |
| Serum P (mg/dL) | 3.5 ± 0.5 | 3.5 ± 0.4 | 0.84 |
| Serum PTH (mg/dL) | 44.7 ± 16.5 | 51.8 ± 26.4 | 0.28 |
| Urinary pH | 7.00 [6.50, 7.25] | 6.75 [6.38, 7.12] | 0.56 |
| Urinary volume (L/day) | 1.25 [0.96, 1.64] | 1.40 [1.05, 1.95] | 0.36 |
| Hypercalciuria | 0 (0.0) | 9 (8.7) | 0.21 |
| Hyperphosphaturia | 2 (6.7) | 3 (2.9) | 0.32 |
| Hypernatriuria | 1 (3.4) | 0 (0.0) | 0.29 |
| Hyperoxaluria | 6 (20.0) | 20 (19.4) | 1.00 |
| Hypocitraturia | 11 (36.7) | 66 (64.1) | 0.01 |
| Urinary Ca (g/day) | 0.12 [0.08, 0.19] | 0.15 [0.09, 0.22] | 0.19 |
| Urinary P (g/day) | 0.60 [0.41, 0.76] | 0.56 [0.40, 0.73] | 0.44 |
| Urinary Na (g/day) | 2.05 [1.52, 3.01] | 2.17 [1.66, 2.92] | 0.96 |
| Urinary Ox (mg/day) | 24.9 [21.0, 34.3] | 23.3 [16.2, 29.1] | 0.21 |
| Urinary Cit (mg/day) | 395 [242, 548] | 296 [178, 458] | 0.07 |
Values are presented as mean ± SD, n (%), or medians [interquartile range]
BMI, body mass index; DM, diabetes mellitus, HLP, hyperlipidemia; HTN, hypertension, PHP, pseudohypoparathyroidism; RTA, renal tubular acidosis; NaKCit, sodium potassium citrate; VitD, vitamin D; BMD, bone mineral density, SD, standard deviation, Ca, calcium, P, phosphorus, PTH, parathyroid hormone; Na, sodium; Ox, oxalate; Cit, citrate