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. 2020 Oct 29;39:229. doi: 10.1186/s13046-020-01748-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Upregulation of UPK1A-AS1 promotes proliferation in HCC cells. a. Results of Gene Set Enrichment Analysis (GSEA)were plotted to visualize the correlation between UPK1A-AS1 and cell cycle gene signatures in HCC sample from TCGA dataset (P < 0.05). b-c. CCK-8 assay was performed to determine the effect of UPK1A-AS1 overexpression on proliferation in SK-Hep-1 (b) and MHCC-97H (c) cells (^**P < 0.01, ^***P < 0.001). d-g. Overexpression of UPK1A-AS1 in SK-Hep-1 (d-e) and MHCC-97H (f-g) cells promoted more cells into S phase than negative control as detected by EdU assay (^*P < 0.05, ^**P < 0.01)