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. 2020 Oct 29;39:229. doi: 10.1186/s13046-020-01748-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — UPK1A-AS1 promotes the G1/S transition of HCC cells. a-d. UPK1A-AS1 increased the ration of cells in S phase in comparison with the negative control in SK-Hep-1 (a-b) and MHCC-97H (c-d) cells (^***P < 0.001). Error bars represent the mean ± S.D. of three independent experiments. e. UPK1A-AS1 increased expression of CyclinD1, CDK2, CDK4 and CDK6 in HCC cells by western blotting. f. UPK1A-AS1-overexpressing cells treated with cis-platinum (40 μM) for 24 h. The cells stained with Annexin V-FITC and PI were subjected to FACS analysis. Error bars represent the mean ± S.D. of triplicate experiments (^**P < 0.01, ^***P < 0.001). h. The expression of caspase-3 and PARP were analyzed using western blottinh in UPK1A-AS1-overexpressing MHCC-97H cells treated with cis-platinum