Fig. 2.

Modulation of TNFα-induced genes by IL6/sIL6R in SF. a Change in mRNA expression upon stimulation with increasing doses of TNFα and a fix dose of IL6/sIL6R (50 ng/ml each) in relation to untreated control. Mean ± SEM from three to eight SF lines (*Kruskal-Wallis with Dunn’s multiple comparisons test; ^#Wilcoxon test). b Protein levels of CCL8 and IL8/CXCL8 upon induction with TNFα (10 ng/ml) and IL6/sIL6R (50 ng/ml each). Mean ± SEM from seven SF lines (*Wilcoxon test). c Percentage of polymorphonuclear and mononuclear leukocytes in cell migration assays (n = 19) (*One-way ANOVA with Tukey’s multiple comparison test)