Table 1.

Bacterial load during pneumococcal meningitis

Bacterial load (log CFU/ml)
	Blood	Spleen	Cerebellum
WT	5.3 (4.5/6)	5.1 (4.6/5.6)	6.2 (5.6/7)
WT + Ac2-26	4.5 (3.5/6.3)	5 (3.5/7.7)	4.5 (3.3/5)**
Fpr1−/−	8 (6.7/9.9)	7 (7/8.7)###	9 (7.1/10.1)###
Fpr1−/− + Ac2-26	6.3 (6/7)	7.2 (6.3/7.5)	5.4 (5/7.5)**
Fpr2−/−	6 (5/7.5)	6 (5/7.2)#	6.9 (6/8.7)
Fpr2−/− + Ac2-26	5.3 (5/5.8)	5.3 (4.9/6.4)	6.2 (4/9)

Data are presented as median (25th/75th percentile). Note significantly increased bacterial loads in the spleen of infected Fpr1^−/− or Fpr2^−/− mice and cerebellum of infected Fpr1^−/− mice compared to infected WT mice (n ≥ 10 each group; Mann-Whitney U test; ^###p = 0.0008 or p = 0.0001 for Fpr1^−/− vs. WT; ^#p = 0.04 for Fpr2^−/− vs. WT), and decreased bacterial loads in the cerebellum of infected WT or Fpr1^−/− mice with Ac2-26 compared to infected WT or Fpr1^−/− mice without Ac2-26 (n ≥ 10 each group; Mann-Whitney U test; **p = 0.004 for WT vs. WT + Ac2-26; p = 0.007 for Fpr1^−/− vs. Fpr1^−/− + Ac2-26) (CFU, colony-forming units; WT, wild type)