Table 4.

Pharmacokinetics properties of selected active constituents analyzed by swissADME server.

Name	GIA	BBB	P-gp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
Amarogentin	Low	No	Yes	No	No	No	No	No
Sawertiamarine	Low	No	No	No	No	No	No	No
ἀ-amyrin	Low	No	No	No	No	No	No	No
β-sitosterol	Low	No	No	No	No	No	No	No
Caesalpinins	High	No	Yes	No	No	No	Yes	Yes
Kutkin	Low	No	Yes	No	No	No	No	No
Vanillic acid	High	No	No	No	No	No	No	No
6-gingerol	High	Yes	No	Yes	No	No	Yes	No
Glycyrrhetic acid	High	No	Yes	No	No	No	No	No
Piperine	High	Yes	No	Yes	Yes	Yes	No	No
Magnoflorine	High	Yes	Yes	Yes	No	No	No	Yes
Alliin	High	No	No	No	No	No	No	No
acetylcysteine	High	No	No	No	No	No	No	No
Thymoquinone	High	Yes	No	No	No	No	No	No
Atropine	High	Yes	No	No	No	No	Yes	No
Hyoscyamine	High	Yes	No	No	No	No	Yes	No
Scopolamine	High	No	No	No	No	No	Yes	No
Belladonnine	High	Yes	No	No	No	Yes	No	Yes
Eufoliatorin	High	No	No	No	No	No	No	No
Eupafolin	High	No	No	Yes	No	No	Yes	Yes
Caffeic acid	High	No	No	No	No	No	No	No