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. Author manuscript; available in PMC: 2021 Sep 9.
Published in final edited form as: Nature. 2020 Sep 9;585(7825):447–452. doi: 10.1038/s41586-020-2690-1

Extended Data Figure 2. Inhibitor selectivity for PLK4, and not other kinases, is required for the synthetic lethal killing of cells overexpressing TRIM37.

Extended Data Figure 2.

(A) Representative data of a 10 day clonogenic survival of indicated MCF-7 cell lines treated with DMSO (control), centrinone, CFI-400945 or ZM447439.

(B) Quantification of (A), n = 3, biological replicates. P values, unpaired two-tailed t-test. Mean ± s.e.m.

(C) Left, representative flow cytometric analysis of DNA content in MCF-7 cells treated with DMSO (control), centrinone, CFI-400945 or ZM447439 for 3 days. Right, quantification of the percentage of cells with >4N DNA content (polyploidy). n = 3, biological replicates. Mean ± s.e.m.