Table 2. Univariate and multivariate analyses based on Cox’s Proportional Hazards Model for disease-specific survival according to the clinicopathological features evaluated before surgery in stage III colorectal cancer patients.

Variables	No. of cases	Univariate Analysis			Multivariate Analysis
		Hazard Ratio	95% Confidence Interval	P value	Hazard Ratio	95% Confidence Interval	P value
Sex
Male/Female	289/223	1.02	0.67-1.55	0.93
Age
≥ 65/< 65	282/230	1.36	0.89–2.09	0.15
Location
Left side/Right side	400/112	1.26	0.76–2.21	0.38
Serum CEA level before surgery (μg/L)
> 5.3/≤ 5.3	178/334	1.67	1.10–2.52	0.017		Not selected
Serum CA19-9 level before surgery (U/ml)
> 37/≤ 37	91/421	1.66	1.00–2.63	0.049		Not selected
Macroscopic type
Type3, 4, 5/Type0, 1, 2	51/461	2.24	1.26–3.73	0.0076	1.82	1.00–3.09	0.047
Maximum diameter of tumor (mm)
≥ 50/< 50	27/275	1.46	0.97–2.22	0.071		Not selected
Tumor intestinal annular propotion
≥ 50/< 50	376/136	2.16	1.25–4.08	0.0049		Not selected
Histological grading
G3/G1, 2	44/468	2.00	1.06–3.48	0.034		Not selected
Depth of tumor
≥ T3/≤ T2	451/61	4.37	1.64–17.79	0.0013		Not selected
Mismatch repair protein
Deficient/Proficient	36/476	1.06	0.45-2.14	0.88
Mesothelin expression
Positive/Negative	61/451	2.32	1.36–3.78	0.0028	2.31	1.34–3.79	0.0033