Table 2.
Time intervals of absolute and relative values referring to the onset of symptoms for blood lymphocytes, monocytes, polymorphonuclear cells and human leucocyte antigens-DR (HLA-DR, expressed in AB/C number of events per cell).
| Variable | A : days 7–10 | B : days 11–14 | C : days 15-J18 | D : days 19–23 | E : days > 24 | Normal range | Miss | P*All | P** A-B | P** A-D | P** A-E | P** B-D | P** B-E |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of patients | 5 | 9 | 12 | 11 | 9 | ||||||||
| Leukocytes (109/l) | 8.12 [7.83; 11.61] | 10.79 [9.68; 11.23] | 10.3 [6.8; 13.79] | 11.48 [10.6; 15.19] | 13.5 [11.7; 14.7] | 4.0–10.0 | 5 | 0.09 | 0.04 | 0.04 | |||
| PMNs (109/l) | 6.26 [5.88; 7.09] | 8.59 [7.79; 9.34] | 6.12 [4.64; 9.07] | 9.06 [8.03; 11.26] | 9.5 [7.6; 11] | 1.5–7.0 | 11 | 0.08 | 0.04 | 0.06 | |||
| Monocytes (109/l) | 0.55 [0.34; 0.96] | 0.52 [0.35; 0.6] | 0.67 [0.27; 0.84] | 0.61 [0.52; 0.79] | 0.9 [0.7; 1] | 0.2–1.0 | 3 | 0.04 | |||||
| Monocytes CD16- (%) | 28.41 [21.26; 54.56] | 69.72 [42.19; 83.76] | 59.51 [41.16; 75.64] | 53.26 [19.73; 66.88] | 56.6 [44.1; 68.3] | 80–85 | 7 | ||||||
| Monocytes Int (%) | 67.51 [39.18; 72.95] | 27.95 [14.57; 48.09] | 37.81 [19.77; 53.92] | 43.18 [30.11; 67.24] | 35.9 [29.3; 53] | 2–11 | 7 | ||||||
| Monocytes CD16+ (%) | 3.04 [2.49; 5.3] | 1.49 [1.06; 7.5] | 2.52 [1.96; 3.77] | 3.96 [1.62; 10.23] | 3.7 [1.2; 7.7] | 2–8 | 7 | ||||||
| HLA (AB/C) | 6396 [3360; 6479] | 3237 [2853; 4173] | 4850 [4033.5; 7193] | 5094 [4170; 7895] | 8406 [3466.5; 11776] | 16884[5842–29175] | 1 | 0.08 | 0.08 | ||||
| HLA CD16- (AB/C) | 4199 [2467; 6680] | 2769 [1897; 4400] | 3422.5 [2762.5; 5499.5] | 4009.5 [2278.5; 6088] | 4922.5 [2515; 6899] | 7 | |||||||
| HLA Int (AB/C) | 8805 [3684; 9510] | 4758.5 [3457.5; 9677] | 7907.5 [4984.5; 12331.5] | 7883 [4416; 12552] | 9623.5 [5756; 20052] | 7 | |||||||
| HLA CD16+ (AB/C) | 34565 [16673; 48542] | 11864 [5352; 30733] | 24179.5 [12204; 33577] | 29197.5 [24749; 42757.5] | 39806.5 [16598; 71223] | 7 | 0.09 | 0.08 | |||||
| Lymphocytes | 1.28 [1.18; 2.05] | 0.54 [0.45; 0.91] | 0.86 [0.63; 1.71] | 1.07 [0.96; 1.44] | 1.8 [1; 2] | 1.0–3.0 | 2 | 0.03 | 0.07 | 0.03 | 0.02 | ||
| LT4 (109/l) | 0.64 [0.57; 0.66] | 0.26 [0.2; 0.44] | 0.46 [0.34; 0.68] | 0.57 [0.45; 0.65] | 0.8 [0.4; 1.1] | 0.55–1.5 | 2 | 0.06 | 0.07 | 0.03 | 0.06 | ||
| LT4 (%) | 50 [27.8; 56.3] | 54.45 [42.65; 57.25] | 48.7 [41.6; 62.05] | 47.9 [42.5; 53] | 48.3 [45.3; 51.8] | 2 | |||||||
| LT8 (109/l) | 0.15 [0.11; 0.94] | 0.07 [0.03; 0.1] | 0.12 [0.04; 0.28] | 0.19 [0.09; 0.2] | 0.3 [0.1; 0.4] | 0.3–1.3 | 2 | 0.02 | 0.08 | 0.02 | <.01 | ||
| LT8 (%) | 11.8 [9.7; 46] | 9.8 [6.1; 14.45] | 14.85 [8.4; 16.1] | 13.6 [8.8; 20] | 16.2 [14.4; 19.2] | 2 | 0.03 | ||||||
| LB (109/l) | 0.32 [0.21; 0.33] | 0.14 [0.1; 0.21] | 0.15 [0.06; 0.56] | 0.21 [0.14; 0.25] | 0.4 [0.2; 0.5] | 0.09–0.6 | 2 | 0.05 | |||||
| LB (%) | 17.8 [16.3; 20.4] | 22.5 [19.85; 25.95] | 20.1 [8.5; 33.1] | 14.6 [11.1; 28.8] | 20.9 [16.3; 26.3] | 2 | |||||||
| L NK (109/l) | 0.11 [0.11; 0.15] | 0.09 [0.04; 0.14] | 0.1 [0.05; 0.14] | 0.15 [0.09; 0.23] | 0.1 [0.1; 0.2] | 0.15–1.1 | 2 | ||||||
| L NK (%) | 8 [5.3; 8.2] | 11.1 [8.35; 18.6] | 11.8 [6.25; 14.5] | 14.5 [7.6; 17] | 7.7 [4.5; 10] | 2 | 0.09 | 0.10 | |||||
| CD4/CD8 | 4.05 [0.62; 5.6] | 5.26 [2.89; 8.57] | 3.83 [2.5; 5.32] | 2.78 [2.52; 5.02] | 2.8 [2.4; 3.3] | 2 | 0.10 | ||||||
| Treg (109/l) | 6.1 [5; 8.3] | 7.85 [6.9; 10.15] | 7.5 [6.5; 10.55] | 9.15 [6; 14.9] | 8.3 [6.5; 9.7] | 3 | 0.88 | ||||||
| PMNs/Lymphocytes | 5.13 [2.72; 5.35] | 15.88 [6.37; 19.06] | 5.46 [2.91; 10.74] | 6.85 [5.72; 11.13] | 7.3 [3.4; 9] | 13 | 0.05 | 0.02 | 0.06 | 016 |
Data are expressed as medians and interquartile [IQ]; LT4: CD4 T-cells; LT8: CD8 T-cells; LB: B-cells; L NK: NK-cells; Treg: Regulatory T-cells; PMNs: polymorphonuclear cells. The right part shows the variations observed over time for all cells (All) or between the periods of blood sampling: A, B, C, D, E. The comparisons between periods B and C, C and D, C and E did not show any significance. *p-value: Kruskall-Wallis test; **p-value: Wilcoxon test.