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. 2020 Oct 14;11:564288. doi: 10.3389/fimmu.2020.564288

Figure 1.

Figure 1

Functional and structural renal injury following IRI. (A, B) Blood urea nitrogen (BUN) and plasma creatinine levels were significantly lower in the JPI-289-treated groups compared with the IRI control group in a dose-dependent manner. (C) Hematoxylin and eosin staining of the cortex of postischemic kidneys. Arrows indicate damaged or necrotic tubules (×200). (D) On day 3 after IRI, the JPI-289-treated groups showed less damaged or necrotic tubules compared to the IRI control group. A total of 10 fields magnified 200× were scored for each mouse by a pathologist blinded to the groups. Data are from three independent experiments. *P < 0.05, compared with the IRI control group (n = 6–10 in each IRI group, n = 5 in the sham control group). Statistical analyses were performed with two-way ANOVA test followed by Newman-Keuls test (A, B) or the Mann-Whitney U test (D).