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. 2020 Oct 14;11:564288. doi: 10.3389/fimmu.2020.564288

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Copyright © 2020 Jang, Lee, Jeon, Kim, Lee, Kwon, Kim, Kim, Ko and Huh

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proliferation of hypoxic HK-2 cells according to the dose of JPI-289. (A) JPI-289 treatment at 0.5 or 0.75 µg/ml facilitated proliferation of hypoxic HK-2 cells compared with the hypoxia control group. Day 0 corresponds to the day when HK-2 cells were taken out from the multi-gas incubator after 48 h of hypoxia. Data are from eight independent experiments. *P < 0.05, compared with the hypoxia control group. Statistical analysis was performed with the Mann-Whitney U test. (B) The proliferation of normoxic HK-2 cells treated with JPI-289 was comparable with that of the normoxia control group. Data are from eight independent experiments.