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. 2020 Oct 14;11:564288. doi: 10.3389/fimmu.2020.564288

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Copyright © 2020 Jang, Lee, Jeon, Kim, Lee, Kwon, Kim, Kim, Ko and Huh

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PARP-1 activities in the postischemic kidney protein extracts on day 3 after IRI. (A) JPI-289 effectively suppressed PARP-1 activity in a dose dependent fashion. Data are from two independent experiments. *P < 0.05, compared with the JPI-289 0.25 µg/ml treated group. Statistical analysis was performed with the Mann-Whitney U test. (B) Intrarenal PARP-1 activities in postischemic kidney protein extracts were lower in the JPI-289-treated mice. Data are from two independent experiments. *P < 0.05, compared with the control group. Statistical analysis was performed with the Mann-Whitney U test.