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. 2020 Oct 29;7(1):e000437. doi: 10.1136/lupus-2020-000437

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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This is a simplified version of the canonical nuclear factor kappa B cell (NF-κB) pathway that is negatively regulated by A20 binding inhibitor of NF-κB (ABIN1) function. Other reviews describe NF-kB signalling and ABIN1 interactions and NF-κB regulation in greater detail.^{9 13} In brief, ABIN1 negatively regulates NF-kB by binding to polyubiquitin moieties on (TAK1, NEMO) inhibiting phosphorylation and degradation of inhibitor of κB-α (IkB-α), preventing nuclear translocation of NF-kB and inhibiting transcription of target immune regulators. Created with Biorender.com. IKK, IκB kinase; TLR, Toll-like receptor.