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. 2020 Jul 15;202(2):226–238. doi: 10.1111/cei.13479

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Fig. 3 — Synovial explant‐conditioned media (ECM) induces glycolysis in dendritic cells (DC). (a) Representative bar graphs demonstrating baseline extracellular acidification rate (ECAR), baseline oxygen consumption rate (OCR), the ECAR : OCR ratio after injection of ECM (10%) over 1, 3 and 6 h. (b) Average Seahorse profiles demonstrating (i) extracellular acidification rate (ECAR) (glycolysis) and (ii) OCR (oxidative phosphorylation) before and after injections of oligomycin, trifluorocarbonylcyanide phenylhydrazone (FCCP) and anti‐mycin A in monocyte‐derived DC (MoDC) treated with 10% ECM for 6 h (n = 5). (c) Representative bar graphs demonstrating baseline ECAR, maximal glycolytic capacity and maximal respiratory capacity in MoDC treated with 10% ECM for 6 h (n = 5). (D) Energy map of MoDC showing a distinct shift in ECM‐treated MoDC towards a glycolytic/energetic phase.